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https://www.nature.com/articles/srep37705
Nov 23, 2016 · An advanced multifunctional, hollow metal-organic framework (MOF) drug delivery system with a high drug loading level and targeted delivery was designed and fabricated for the first time and applied to inhibit tumour cell growth.Author: Xuechuan Gao, Xiao Hai, Huricha Baigude, Weihua Guan, Zhiliang Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845978/
Oral pulsatile drug delivery systems that release drug after a lag period of 6–7 h usually release drug in large intestine however, the viscous contents of lower part of GI tract cause hindrance to the drug diffusion and also enzymatic degradation of some drugs makes it an unfavorable site for drug release.Author: Maryam Maghsoodi, Elham Hemati, Bahram Qadermazi, Zahra Yari
http://ijpsr.com/bft-article/preparation-and-evaluation-of-hollow-microsphere-drug-delivery-system-of-zidovudine/
preparation and evaluation of hollow microsphere drug delivery system of zidovudine Abstract Zidovudine is the first approved compound for the treatment of HIV; however the main limitation to therapeutic effectiveness of Zidovudine is its dose dependent toxicity, short biological half-life and poor bioavailability.
https://pubs.acs.org/doi/abs/10.1021/acsami.9b20510
Hollow mesoporous silica microsphere (HMSM) particles are one of the most promising vehicles for efficient drug delivery owing to their large hollow interior cavity for drug loading and the permeable mesoporous shell for controlled drug release. Here, we report an easily controllable aerosol-based approach to produce HMSM particles by continuous spray-drying of colloidal silica nanoparticles ...Author: Jalal Poostforooshan, Sabrina Belbekhouche, Masoom Shaban, Vanessa Alphonse, Damien Habert, Noureddi...
https://www.sciencedirect.com/science/article/pii/S0928493116300546
Porous hollow hydroxyapatite microspheres (PHHMs) are the promising biomaterials, owing to their excellent biocompatibility, biodegradability and bioactivity. PHHMs have been used as drug controlled carriers due to their advantages such as large drug loading capacity, nanochannels for drug loading and release and high specific surface area.Author: Wen Lai, Cen Chen, Xiaoyuan Ren, In-Seop Lee, Guohua Jiang, Xiangdong Kong
https://www.pharmatutor.org/articles/microsphere-drug-carrier-review
Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microsphere which modulates the release and absorption characteristics of the drug. These delivery systems offer numerous advantages over the conventional dosage forms including improved efficacy, reduced toxicity, and improved patient compliance. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs…
http://ijpsr.com/bft-article/microspheres-as-drug-carriers-for-controlled-drug-delivery-a-review/?view=fulltext
ABSTRACT: Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. Microspheres have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, to simulate controlled drug release.
https://www.slideshare.net/AnindyaJana/drug-delivery-through-microspheres
Apr 20, 2017 · Microspheres are spherical & free flowing particles ranging in average particle size from 1 to 50 microns which consist of proteins or synthetic polymers. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug. One such approach is using microspheres as carriers for drugs.
https://www.jgtps.com/admin/uploads/YqxI0h.pdf
Microspheres received much attention not only for prolonged release, but also for targeting of drugs. In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials, targeted and effective drug delivery. The current aim of this review is to studyFile Size: 1MB
https://www.sciencedirect.com/science/article/pii/S0928493113002026
Interestingly, the hollow structure of the HCHAs is not detected, since the broken microspheres are covered with the bone-like apatite nanoparticles. The slow drug release at the late stage for systems of the VCN-loaded HCHAs is associated with these bone-like nanoparticles, which hold back the drug release from the hollow microspheres.Author: Ya-Jun Guo, Ying-Ying Wang, Ting Chen, Yi-Ting Wei, Lian-Feng Chu, Ya-Ping Guo
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