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https://www.sciencedirect.com/topics/neuroscience/hepatic-portal-system
The hepatic portal system is the venous system that returns blood from the digestive tract and spleen to the liver (where raw nutrients in blood are processed before the blood returns to the heart). Essentially, it drains the structures supplied ultimately by the celiac (except for the gonads), anterior mesenteric, gastrosplenic, and posterior mesenteric arteries.
https://quizlet.com/268106959/nutrition-chapter-21-lo-flash-cards/
Hepatic portal system is part of intestinal phase. nutrients that enter circulatory system go directly to the hepatic portal system. liver is an important filter and has over 500 different roles-metabolizes drugs, toxins, xenobiotics-major hurdle for drug design and delivery
https://www.hindawi.com/journals/bmri/2013/382184/
Normally most of the drugs achieve high hepatic concentration, still their targeting is necessary because liver is the major organ in the body equipped for uptake, detoxification, metabolic transformation, and excretion of xenobiotics into bile by means of carrier-mediated mechanism.Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
https://quizlet.com/22732419/dosage-forms-vaginal-drug-delivery-flash-cards/
Dosage forms- vaginal drug delivery. STUDY. PLAY. most common purpose of vaginal route. ... Is venous drainage through the hepatic portal system? no. variations in vaginal mucosa. amount and composition of vaginal fluid, ph, and epithelium ... long enough for the drug to distribute adequately- rheology andlevel of insertion can be important.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438887/
Biodegradable and bioerodible polymers represent an important class of materials for drug delivery. Although often used interchangeably, degradation and erosion differ in that covalent bond cleavage by chemical reactions occurs in degradation.Author: William B. Liechty, David R. Kryscio, Brandon V. Slaughter, Nicholas A. Peppas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744959/
Apr 20, 2012 · The CYP450 enzyme system is a key pathway for drug metabolism. Most of the lipophilic drugs must undergo biotransformation to more hydrophilic compounds to be excreted from the body. Drug biotransformation reactions consist of Phase I (e.g., oxidation, reduction) or Phase II (e.g., conjugation) reactions that occur primarily in the liver.Author: Yogeshkumar Nanasaheb Gavhane, Adhikrao Vyankatrao Yadav
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