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https://www.sciencedirect.com/topics/medicine-and-dentistry/hepatic-clearance
Jitender Madan, in Drug Targeting and Stimuli Sensitive Drug Delivery Systems, 2018. 15.4.4.1.4 Increased potential for first pass clearance. Hepatic clearance is a saturated process. After oral dosing, the drug reaches the liver by travelling through portal vein. The concentration of drug that reaches the liver determines the amount metabolized.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826320/
Oct 28, 2013 · Site-specific drug delivery ensures that such interactions take place only in the desired anatomical location of the liver; therefore, it must fulfil the following criteria: (i) it must be able to cross the anatomical barriers such as those of stomach and intestine, (ii) should be recognized selectively by the receptor present on liver cell such as asialoglycoprotein, (iii) exogenously delivered ligand for …Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
http://tmedweb.tulane.edu/pharmwiki/doku.php/hepatic_drug_clearance
The ratio of the hepatic clearance of a drug to the hepatic blood flow is called the extraction ratio of the drug. Extraction ratio can be generally classified as high (>0.7), intermediate (0.3-0.7) or low (<0.3) according to the fraction of drug removed during one pass through the liver.
https://derangedphysiology.com/main/cicm-primary-exam/required-reading/pharmacokinetics/Chapter%203336/hepatic-clearance
The two major determinants of hepatic clearance are the efficiency of drug removal from the blood and the efficiency of blood delivery to the liver. The former is described by the hepatic extraction ratio, and the latter is simply the blood flow to the liver.
https://www.researchgate.net/publication/260643363_Recent_Advances_in_Active_Hepatic_Targeting_Drug_Delivery_System
Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases.
https://clincancerres.aacrjournals.org/content/12/8/2563
Apr 15, 2006 · We studied a new drug delivery system comprising microspheres, with unique properties allowing delivery of large amounts of drugs to tumors for a prolonged time, thereby decreasing plasma levels. Liver tumors, unlike nontumorous liver, draw most of their blood supply from the hepatic artery.Author: Kelvin Hong, Afsheen Khwaja, Eleni A Liapi, Michael S. Torbenson, Christos S Georgiades, Jean Franco...
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