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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835126/
Apr 30, 2009 · Gene therapy covers a broad spectrum of applications, from gene replacement and knockdown for genetic or acquired diseases such as cancer, to vaccination, each with different requirements for gene delivery. Viral vectors and synthetic liposomes have emerged ...Author: Yiqi Seow, Matthew J Wood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.nidcr.nih.gov/news-events/nidcr-news/pioneering-gene-therapy-dry-mouth
The researchers then designed a second clinical trial using a different gene delivery vehicle, based on an adeno-associated virus. The newer viral vector was designed to transfer the same aquaporin 1 gene to the salivary glands of cancer patients with radiation-induced dry mouth.
https://engene.com/science/
Jul 10, 2017 · In designing the Gene Pill™, we chose to move away from the conventional gene delivery paradigm that uses viruses as carriers of genetic payloads. Our proprietary non-viral DDX® vehicle is a synthetic polymer that is highly efficient in packaging DNA.
https://www.sciencedirect.com/science/article/pii/S0378517313010351
The key to success of gene therapy is to create safe and efficient gene delivery vehicles. Ideally, the vehicle must be able to remain in the bloodstream for a long time and avoid uptake by the mononuclear phagocyte system, in order to ensure its arrival at the desired targets.Author: D. Ibraheem, A. Elaissari, H. Fessi
https://www.unmc.edu/pharmacy/research/cntr/researchers/mahato7.pdf
Mesenchymal Stem Cells as a Gene Delivery Vehicle for Successful Islet Transplantation Hao Wu & Wenli Lu & Ram I. Mahato Received: 18 February 2011 /Accepted: 14 March 2011 # Springer Science+Business Media, LLC 2011 ABSTRACT Purpose To evaluate the efficacy of human bone marrow-derived mesenchymal stem cells (hBMSCs) as gene
https://www.registerguard.com/news/20200305/plant-based-relatives-of-cholesterol-could-help-gene-therapy-for-cystic-fibrosis-other-diseases
Mar 05, 2020 · Gaurav Sahay, assistant professor of pharmaceutical sciences in the OSU College of Pharmacy, studies lipid-based nanoparticles as a gene delivery vehicle, with a focus on cystic fibrosis.
https://www.hindawi.com/journals/isrn/2013/397243/
The majority of viral vectors currently used possess modest cargo capability (up to 40 kb) being based on retroviruses, lentiviruses, adenoviruses, and adenoassociated viruses. These vectors have made the most rapid transition from laboratory to clinic because their small genomes have simplified their characterization and modification. However, there is now an increasing need both in ...Author: Filip Lim
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