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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · Viral vectors based on RNA for gene delivery have developed for the ability to transcribe directly for infectious RNA transcripts. RNA-based gene delivery is not permanent and usually transient. In the gene delivery systems based on RNA, human foamy virus, oncoretro-viral vectors, and lenti-viral vectors are included in the gene therapy.Author: YK Sung, SW Kim
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Continuing with the series of articles on gene therapy, this article will discuss the various delivery methods for gene therapies with a focus on viral vectors.The article also discusses the classific
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies.html
Viral delivery: Highest efficiency amongst gene delivery methods (80–90% transduction efficiency in primary cells) Works well with difficult to transfect cell types; Can be used for in vivo delivery of nucleic acids; Can be used for making stable cell lines (retroviral …
https://systembio.com/applications/gene-delivery/
Exosome Engineering—use exosomes as a non-viral method for gene delivery; Syn2Clone Custom Constructs—keep your hands off your pipettes with this service where you simply email us your gene sequence. We synthesize the gene and clone it into the SBI construct of your choice, all for little more than the cost of the empty vector.
https://www.cell.com/molecular-therapy-family/methods/pdf/S2329-0501(19)30020-8.pdf
the versatile vectors for therapeutic gene delivery in both dividing and non-dividingcells forthetreatmentof monogenicdisease condi-tions.1,2 The regulatory approval of Glybera by the European Medi-cines Agency (EMA) in 2012 for lipoprotein lipase deficiency3 andFile Size: 1007KB
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-019-0156-z
Mar 12, 2019 · An important goal for the research of gene delivery system is to develop clinically relevant vectors that use to combat elusive diseases such as AIDS, cancer, Alzheimer, etc. DNA-based viral vectors for gene delivery systems utilize the viral vectors to deliver genetic materials to the host cells.Author: YK Sung, SW Kim
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