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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Retroviruses are useful for ex vivo delivery of somatic cells because of their ability to linearly integrate into host cell genome; for example, they have been used for human gene therapy of X-SCID successfully but incidence of leukemia in some patients occurred because of integration of retroviruses to the LMO2 gene and inappropriate activation of it.[29–34] Retroviral vectors also have been applied for familial hyperlipidemia gene …
https://www.sciencedirect.com/science/article/pii/B9780124371651500123
The 170 Gene delivery using retroviral vectors ability of HIV-1 to infect non-dividing cells in the CNS suggests the possibility of pseudotyping MMLV and HIV-1 viruses for gene delivery. Attempts to create a pseudotyped MMLV by introducing analogous matrix and capsid proteins from HIV- 1 did not result, however, in a functional virus (Deminie and Emerman, 1993).Author: Miguel Sena-Esteves, Manish Aghi, Peter A. Pechan, Edward M. Kaye, Edward M. Kaye, Xandra O. Breakef...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182074/
Retroviral gene therapy approaches for the treatment of these diseases have to address safety issues. Targeted infection, local delivery, targeted retroviral insertion, insulators, transcriptional targeting, co-transduction with a suicidal gene, and SIN vectors were suggested as possible solutions for the risks of retroviral gene therapy.Author: Youngsuk Yi, Moon Jong Noh, Kwan Hee Lee
https://www.nature.com/articles/3301043
Jan 05, 2000 · In the retroviral vectors used in this study, a scA against the human Her2neu protein, a cell surface protein belonging to the tyrosine-kinase (epidermal growth factor) receptor family, has been fused to the transmembrane domain (TM) of the SNV envelope (env) protein (gene …Author: A Jiang, R Dornburg
https://web.stanford.edu/group/nolan/_OldWebsite/tutorials/ret_1_advant.html
Retroviruses have a number of features that make them unique as gene delivery vehicles.Their life cycle includes an integrated state in the DNA of the host chromosome.
https://www.youtube.com/watch?v=21nx9dRTP18
Dec 09, 2013 · This gene therapy video tutorial is to explain the method of gene therapy using retrovirus vector to cure genetic diseases. One example of such retrovirus is lentivirus. For more information, log...Author: Shomu's Biology
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