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https://link.springer.com/chapter/10.1007/12_023
Nov 08, 2005 · The use of polymers as synthetic non-viral carriers for introducing nucleic acids into cells appears very appealing. Polymers can be generated in large quantities in chemically defined,... Gene Delivery Using Polymer Therapeutics SpringerLink
https://www.researchgate.net/publication/226242749_Gene_Delivery_Using_Polymer_Therapeutics
Nucleic acid delivery, however, remains a main challenge in human gene therapy. Polymer-based delivery systems offer a safer and promising route for therapeutic gene delivery.
https://www.springer.com/gp/book/9783540292104
Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities Pages 1-8 Duncan, Ruth (et al.)
https://www.intechopen.com/books/advanced-technology-for-delivering-therapeutics/biopolymer-in-gene-delivery
The use of biopolymers as nanoparticles in gene delivery can potentially avoid many of the safety concerns in the gene delivery system. In gene delivery, the genetic materials such as DNA plasmids, RNA and siRNA are either encapsulated inside or conjugated to the nanoparticles, which protects the genetic materials until the drug reaches its target site.Author: Sakthivel Lakshmana Prabu, Kandasamy Ruckmani
https://link.springer.com/article/10.1007%2Fs12272-013-0275-3
Nov 01, 2013 · Abstract. Bioreducible polymers, which can be degraded in reducing environment due to the cleavage of internal disulfide bonds, have been developed for gene delivery systems. They show high stability in extracellular physiological condition and cytoplasm-specific release of genetic materials, as well as decreased cytotoxicity because cytoplasm is...Author: Kitae Ryu, Tae-il Kim
https://www.sciencedirect.com/science/article/abs/pii/S0168365902000093
Pluronic ® block copolymers are found to be an efficient drug delivery system with multiple effects. The incorporation of drugs into the core of the micelles formed by Pluronic ® results in increased solubility, metabolic stability and circulation time for the drug.Author: Alexander V Kabanov, Elena V Batrakova, Valery Yu Alakhov
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