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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · Viral and nonviral delivery systems for gene delivery. ... There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus. ... cationic systems are mad of either a single synthetic ...
https://www.sciencedirect.com/science/article/pii/S0065266005530025
Synthetic vectors based on polycations are promising vectors for gene delivery as they are relatively safe and can be modified by the incorporation of ligands for targeting to specific cell types. However, the levels of gene expression mediated by synthetic vectors are low compared to viral vectors.Author: Martin L. Read, Ann Logan, Leonard W. Seymour
https://www.researchgate.net/publication/7523614_Barriers_to_Gene_Delivery_Using_Synthetic_Vectors
Synthetic vectors based on polycations are promising vectors for gene delivery as they are relatively safe and can be modified by the incorporation of ligands for targeting to specific cell types.
https://www.sciencedirect.com/science/article/pii/S2329050119300051
In fact, recovering specific native phenotypes using viral vectors is difficult, because many genes are expressed in the same cell type or one gene is expressed in a wide range of inner ear cell types. 36 Therefore, using rAAV vectors with tissue tropism patterns distinct from rAAV2/DJ may enable more effective and accurate gene transport to ...Author: Min-A Kim, Min-A Kim, Nari Ryu, Nari Ryu, Hye-Min Kim, Hye-Min Kim, Ye-Ri Kim, Ye-Ri Kim, Byeonghyeo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · DNA-based viral vectors for gene delivery systems utilize the viral vectors to deliver genetic materials to the host cells. ... The gene delivery systems based on synthetic polymeric materials have tested and evaluated for gene transfer to animals . One of the candidates is the plasmid DNA that is able to carry the gene into the nucleus of the ...Author: YK Sung, SW Kim
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(19)30005-1
Jun 14, 2019 · Targeted Gene Delivery into the Mammalian Inner Ear Using Synthetic Serotypes of Adeno-Associated Virus Vectors. Min-A Kim 7. Author Footnotes. 7 These authors contributed equally to this work. Min-A Kim. ... Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nat. Biotechnol. 2006; 24: 198-204.Author: Min-A Kim, Min-A Kim, Nari Ryu, Nari Ryu, Hye-Min Kim, Hye-Min Kim, Ye-Ri Kim, Ye-Ri Kim, Byeonghyeo...
https://www.researchgate.net/publication/230019047_Synthetic_polyamines_as_vectors_for_gene_delivery
We report the synthesis and physicochemical evaluation of a series of cationic polymethacrylates as vectors for gene delivery. Two different types of polymer have been synthesized: The first is a ...
https://www.future-science.com/doi/abs/10.4155/tde.12.128
In this review, synthetic vectors that allow the controlled design of efficient and biocompatible carriers are highlighted. The current benefits, potentials, problems and unmet needs of synthetic gene delivery systems, as well as the strategies to overcome the obstacles are also discussed.Author: Florian Schlenk, Stefan Grund, Dagmar Fischer
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