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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083003/
Sep 07, 2018 · Delivery of genes to mouse liver is routinely accomplished by tail-vein injections of viral vectors or naked plasmid DNA. While viral vectors are typically injected in a low-pressure and -volume fashion, uptake of naked plasmid DNA to hepatocytes is facilitated by high pressure and volumes, also known as hydrodynamic delivery.Author: Trine Dalsgaard, Claudia R. Cecchi, Anne Louise Askou, Rasmus O. Bak, Pernille O. Andersen, David Ho...
https://www.ncbi.nlm.nih.gov/pubmed/30783984
AAV-Mediated Gene Delivery to the Liver: Overview of Current Technologies and Methods. ... Looking beyond gene replacement, recent technologies offer the possibility for AAV liver gene transfer to directly repair deficient genes and potentially treat autoimmune disease.Author: Brett Palaschak, Roland W. Herzog, Roland W. Herzog, David M. Markusic
https://ir.uiowa.edu/etd/1577/
Gene therapy is being intensively studied as a potential method to treat many disorders, including disorders of the liver. While viral gene therapy has seen some success, possible side effects make it risky, so nonviral gene delivery vectors are being developed.Author: Samuel Thomas Crowley
https://www.nature.com/articles/3301840
Jan 13, 2003 · For liver gene delivery, both virus-mediated 3 4 5 and non-viral systems have been considered. Although some of the virus-mediated gene transfer …Author: M A Arangoa, N Düzgüneş, C Tros de Ilarduya
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · There are many kidney diseases that might be addressed by gene therapy. However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.nature.com/articles/s41467-019-10893-8
Jul 05, 2019 · The high surface PEGylation tolerance and a small particle size, which could direct the particles away from Kupffer cells (KCs) 31, confer LCPs advantages for liver-specific gene delivery.Author: Mengying Hu, Ying Wang, Ligeng Xu, Ligeng Xu, Sai An, Yu Tang, Xuefei Zhou, Jingjing Li, Rihe Liu, L...
https://www.sciencedirect.com/science/article/pii/S1525001616327198
For example, Zhang et al. have shown in rats that the volume required for successful hydrodynamic gene delivery can be reduced to ∼3 ml in a 200–250 g rat (<1.5% of body weight) by targeting an isolated liver through the hepatic vein. 28 Using image-guided catheter insertion under fluoroscopy, Eastman et al. demonstrated in rabbits that a ...Author: Takeshi Suda, Dexi Liu
https://science.sciencemag.org/content/287/5456/1253.full
Feb 18, 2000 · Accelerated telomere loss has been proposed to be a factor leading to end-stage organ failure in chronic diseases of high cellular turnover such as liver cirrhosis. To test this hypothesis directly, telomerase-deficient mice, null for the essential telomerase RNA (mTR) gene, were subjected to genetic, surgical, and chemical ablation of the liver.Author: Karl Lenhard Rudolph, Sandy Chang, Melissa Millard, Nicole Schreiber-Agus, Ronald A. DePinho
https://www.researchgate.net/publication/334259272_Relaxin_gene_delivery_mitigates_liver_metastasis_and_synergizes_with_check_point_therapy
Relaxin gene delivery mitigates liver metastasis. and synergizes with check point therapy. Mengying Hu 1, Ying Wang 1,2, Ligeng Xu 1,3, Sai An 1, Yu Tang 4, Xuefei Zhou 1, Jingjing Li 2, Rihe Liu 2 &
https://ashpublications.org/blood/article/122/12/2030/31677/Specific-gene-delivery-to-liver-sinusoidal-and
Sep 19, 2013 · This explains the efficient gene delivery observed for mCD105-LV and for huCD105-LV in EC-transplanted mice. We did, however, also observe gene transfer into ECs exposed to high blood flow, ie, into transplanted arteries, upon systemic administration of huCD105-LV.Author: Tobias Abel, Ebtisam El Filali, Johan Waern, Irene C. Schneider, Qinggong Yuan, Robert C. Münch, Mei...
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