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https://www.ncbi.nlm.nih.gov/pubmed/14970596
The efficient transduction of postmitotic cells by adeno-associated virus (AAV) makes it an excellent vector to deliver marker, functional, or therapeutic genes to the mammalian brain.Author: Marco A. Passini, Marco A. Passini, Deborah J. Watson, Deborah J. Watson, John H. Wolfe, John H. Wol...
https://link.springer.com/protocol/10.1385/1-59259-650-9:225
Passini, M. A. and Wolfe, J. H. (2001) Widespread gene delivery and structure-specific patterns of expression in the brain from an adeno-associated virus vector following intraventricular injections of neonatal mice.Author: Marco A. Passini, Marco A. Passini, Deborah J. Watson, Deborah J. Watson, John H. Wolfe, John H. Wol...
https://www.researchgate.net/publication/7405909_Gene_delivery_to_the_mouse_brain_with_adeno-associated_virus
AAV serotype 2 has widely been used as a means of brain gene delivery with features of safety, neuronal-and injection site-specific infection, and maintaining gene expression for long periods ...
https://www.nature.com/articles/s41573-019-0012-9
Feb 01, 2019 · Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids, optimizing genome designs and harnessing revolutionary biotechnologies have contributed substantially to the growth of the gene therapy field.Author: Dan Wang, Phillip W. L. Tai, Guangping Gao
https://www.ncbi.nlm.nih.gov/pubmed/27318144
Using several administration protocols, we now report that direct intracerebral adeno-associated virus (AAV)-mediated delivery of APOE2 markedly reduces brain soluble (including oligomeric) and insoluble Aβ levels as well as amyloid burden in 2 mouse models of brain amyloidosis whose pathology is dependent on either the expression of murine Apoe or more importantly on human APOE4.Author: Lingzhi Zhao, Andrew J. Gottesdiener, Mayur Parmar, Mingjie Li, Stephen M. Kaminsky, Maria J. Chiuch...
https://www.nature.com/articles/s41417-018-0077-3
Jan 09, 2019 · Broekman ML, Comer LA, Hyman BT, Sena-Esteves M. Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain.Author: Sherif G. Ahmed, Ahmed Abdelanabi, Mohamed Doha, Gary J. Brenner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156185/
We recently showed that widespread gene delivery can be achieved by injecting an adeno-associated virus type 2 (AAV2) vector directly into the cerebral lateral ventricles at birth, and allowing the cerebrospinal fluid to deliver the virus throughout the CNS . However, many areas of the brain did not show substantial transduction with this experimental strategy.Author: Marco A. Passini, Deborah J. Watson, Charles H. Vite, Daniel J. Landsburg, Alyson L. Feigenbaum, Joh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788045/
Aug 11, 2009 · Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery James T Koerber , 1 Ryan Klimczak , 2 Jae-Hyung Jang , 1 Deniz Dalkara , 1 John G Flannery , 2 and David V Schaffer 1 1 Department of Chemical Engineering, Department of Bioengineering, and the Helen Wills Neuroscience Institute, The University of California ...Author: James T Koerber, Ryan Klimczak, Jae-Hyung Jang, Deniz Dalkara, John G Flannery, David V Schaffer
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · However, gene delivery to kidney cells is inefficient. This is due, in part, to the fact that the kidney excludes molecules above 50 kDa and that most gene delivery vectors are megaDaltons in mass. We compared the ability of adeno-associated virus (AAV), adenovirus (Ad), and lentiviral (LV) vectors to deliver genes to renal cells.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://academic.oup.com/biolreprod/article/96/1/221/2725480
Dec 20, 2016 · In addition to random transgene integration by virus-mediated approaches, genetic selection using germline stem (GS) cells, cultured spermatogonia enriched for SSCs, eventually enabled modification of specific target genes by homologous recombination [7,8].Author: Satoshi Watanabe, Mito Kanatsu-Shinohara, Mito Kanatsu-Shinohara, Narumi Ogonuki, Shogo Matoba, Atsu...
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