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https://www.ncbi.nlm.nih.gov/pubmed/18318652
Moved Permanently. The document has moved here.Author: Xiaobin Zhao, Hong Li, Robert J Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098497/
Our studies further indicate that folate-targeted delivery of As 2 O 3 with coencapsulated nickel(II) ions (as a nontoxic adjuvant) potentiates the As 2 O 3 efficacy in relatively insensitive solid tumor–derived cells and holds the promise of improving drug therapeutic index.Author: Haimei Chen, Richard Ahn, Jeroen Van den Bossche, David H. Thompson, Thomas V. O'Halloran
https://www.nibib.nih.gov/news-events/newsroom/researchers-renew-obsolete-concept-using-folate-cancer-drug-delivery
Sep 06, 2019 · “Folate targeting has been an elusive approach to cancer therapy,” said David Rampulla, Ph.D., director of the NIBIB Division of Discovery Science and Technology. “This team has demonstrated an efficient drug delivery system and shown how a nanoparticle combined with …
https://www.sciencedirect.com/science/article/pii/S014296121300183X
Chemotherapeutic agents often cause severe side effects because they produce a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both tumor microenvironment-sensitive polypeptides (TMSP) and folate to create a more selective and efficient drug delivery system to target cancer cells.Author: Wei Gao, Bai Xiang, Ting-Ting Meng, Feng Liu, Xian-Rong Qi
https://www.sciencedirect.com/science/article/pii/S0927776515001629
Folate mediated self-assembled phytosterol-alginate nanoparticles for targeted intracellular anticancer drug delivery Author links open overlay panel Jianting Wang a 1 Ming Wang b c 1 Mingming Zheng d 1 Qiong Guo a Yafan Wang c Heqing Wang c Xiangrong Xie c Fenghong Huang d Renmin Gong aAuthor: Jianting Wang, Ming Wang, Mingming Zheng, Qiong Guo, Yafan Wang, Heqing Wang, Xiangrong Xie, Fenghon...
https://www.hindawi.com/journals/jnm/2020/7147130/
A dual-targeting drug delivery system (DTDDS) with magnetic targeting and active targeting was obtained to improve the targeting and drug-loading capacity of magnetic drug nanocarriers. An ultraviolet-visible spectrophotometer and flow cytometry were used to investigate the drug-loading and release capacity, cytotoxicity, and inhibition of tumor cell proliferation, separately. Results show ...Author: Jinglei Du, Qiang Li, Lin Chen, Shicai Wang, Li Zhang, Shiping Yu, Shiping Yu, Yongzhen Yang, Xuguan...
https://www.tandfonline.com/doi/abs/10.1517/17425247.5.3.309
Dec 07, 2012 · Targeted delivery via selective cellular markers can potentially increase the efficacy and reduce the toxicity of therapeutic agents. The folate receptor (FR) has two glycosyl phosphatidylinositol (GPI)-anchored isoforms, α and β. FR-α expression is frequently amplified in epithelial cancers, whereas FR-β expression is found in myeloid leukemia and activated macrophages associated with ...Author: Xiaobin Zhao, Hong Li, Robert J Lee
https://medicalxpress.com/news/2019-09-renew-obsolete-concept-folate-cancer.html
Sep 09, 2019 · Thus, in the past, the use of folate for specific drug delivery has not been successful. The OSU team, led by senior author Peixuan Guo, Ph.D., the Sylvan G. Frank Endowed Chair in Pharmaceutical ...
https://www.tandfonline.com/doi/abs/10.3109/10611869909085499
Oct 20, 2008 · (1999). Folate-mediated Drug Delivery: Effect of Alternative Conjugation Chemistry. Journal of Drug Targeting: Vol. 7, No. 3, pp. 157-169.Author: Leamon Cp, DePrince Rb, Hendren Rw
https://www.hindawi.com/journals/jnm/2017/2069685/
The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared with …Author: Xiaoyan Xu, Chao Wu, Andi Bai, Xuan Liu, Huiling Lv, Ying Liu
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