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https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pubmed/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L(1), Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Author information: (1)Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Examples of anticipated results in which exosome-mediated siRNA delivery is evaluated by functional assays and imaging are also provided. ... Delivery of siRNA to the mouse brain …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://altogen.com/InVivoTransfection3.pdf
siRNA was used for the empirical optimization of the electropora-tion protocol. The amount of encapsulated siRNA was assayed after ultracentrifugation and lysis of exosomes (Supplementary Fig. 3a,b). Electroporation at 400 V and 125 µF resulted in the greatest retention Delivery of sirNA to the mouse brain by systemic injection of targeted ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204174/
Aug 11, 2014 · Our results confirmed that systemic siRNA RVG-exosome treatment decreased the total levels of human S129D α-Syn protein throughout the brain, including the midbrain, cortex, and striatum, which are important areas affected by α-Syn deposition at different stages of PD pathology.Author: JM Cooper, PB Wiklander, JZ Nordin, R Al-Shawi, MJ Wood, M Vithlani, AH Schapira, JP Simons, S El-An...
https://www.sigmaaldrich.com/catalog/papers/21423189
Nature biotechnology 2011-3-23 Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. [Lydia Alvarez-Erviti, Yiqi Seow, Haifang Yin, Corinne Betts, Samira Lakhal, Matthew J A …
https://www.sciencedirect.com/science/article/pii/S0168365919306492
One of the major obstacles in brain-targeting gene delivery through IV injection is the blood-brain barrier (BBB), which reduces delivery efficiency dramatically. Therefore, carriers that can bypass or penetrate the BBB efficiently are needed for successful targeted delivery of therapeutic genes into the brain through IV injection.Author: Gyeungyun Kim, Minkyung Kim, Youngki Lee, Jung Woo Byun, Do Won Hwang, Minhyung Lee
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