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https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Examples of anticipated results in which exosome-mediated siRNA delivery is evaluated by functional assays and imaging are also provided. ... Delivery of siRNA to the mouse brain …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.ncbi.nlm.nih.gov/pubmed/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L(1), Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Author information: (1)Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://pubs.acs.org/doi/abs/10.1021/acsnano.6b03858
Traumatic brain injuries (TBIs) affect 2.5 million Americans per year, and survivors of TBI can develop long-term impairments in physical, cognitive, and psychosocial functions. Currently, there are no treatments available to stop the long-term effects of TBI. Although the primary injury can only be prevented, there is an opportunity for intervention during the secondary injury, which persists ...Author: Ester J. Kwon, Matthew Skalak, Riana Lo Bu, Sangeeta N. Bhatia
https://www.researchgate.net/profile/Haifang_Yin/publication/50596721_Alvarez-Erviti_L_Seow_Y_Yin_H_Betts_C_Lakhal_S_and_Wood_MJA_Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes_Nat_Biotechnol_29_341-345/links/0fcfd507cae85f1a2e000000/Alvarez-Erviti-L-Seow-Y-Yin-H-Betts-C-Lakhal-S-and-Wood-MJA-Delivery-of-siRNA-to-the-mouse-brain-by-systemic-injection-of-targeted-exosomes-Nat-Biotechnol-29-341-345.pdf
Delivery of sirNA to the mouse brain by systemic injection of targeted exosomes. ... Next, we investigated the potential for exosome-mediated systemic siRNA delivery . in vivo. To characterize the ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668387/
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29, 341–345 (2011). Yin Y. et al. . Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Res 24, 1164–1180 (2014). [PMC free article] Cho J. A. et al. .Author: Yuchen Liu, Dameng Li, Zhengya Liu, Yu Zhou, Danping Chu, Xihan Li, Xiaohong Jiang, Dongxia Hou, Xi ...
https://www.sciencedirect.com/science/article/pii/S0168365919306492
Brain-targeting exosomes have been studied extensively for application of therapeutic siRNA delivery to address neurodegenerative diseases . The most prominent ligand for brain-targeting exosomes is RVG [, , ]. RVG was first identified for brain-targeting delivery of siRNA as a fusion peptide with 9R . The results suggested that RVG may ...Author: Gyeungyun Kim, Minkyung Kim, Youngki Lee, Jung Woo Byun, Do Won Hwang, Minhyung Lee
https://www.sciencedirect.com/science/article/pii/S0169409X12002438
Next, the potency of RVG-exosome-mediated delivery of siRNA to brain was tested by delivery of BACE-1 siRNA (targeting the enzyme β-secretase and highly relevant to Alzheimer's disease therapy) which resulted in specific and highly significant BACE-1 gene knockdown (60%) in the mouse brain …Author: S El Andaloussi, S Lakhal, I Mäger, Wood Mja.
https://www.sigmaaldrich.com/catalog/papers/21423189
Nature biotechnology 2011-3-23 Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. [Lydia Alvarez-Erviti, Yiqi Seow, Haifang Yin, Corinne Betts, Samira Lakhal, Matthew J A …
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0461-7
Feb 19, 2019 · Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. ... Alvarez-Erviti L, Seow YQ, Yin HF, Betts C, Lakhal S, Wood MJA. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341-U179.Author: Huixin Zhang, Jin Wu, Jiahuan Wu, Qi Fan, Jingchao Zhou, Junwen Wu, Sichen Liu, Jie Zang, Jinhai Ye,...
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