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https://www.ncbi.nlm.nih.gov/pubmed/18176115
Reconstituted (synthetic) high-density lipoprotein particles carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier. The rHDL/PTX complexes seemed to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability even after ultracentrifugation and storage for …Author: Walter J. McConathy, Maya P. Nair, Sulabha Paranjape, Linda Mooberry, Andras G. Lacko
https://www.researchgate.net/publication/5674304_Evaluation_of_syntheticreconstituted_high_density_lipoproteins_rHDL_as_delivery_vehicles_for_paclitaxel
Evaluation of synthetic/reconstituted high density lipoproteins (rHDL) as delivery vehicles for paclitaxel Article (PDF Available) in Anti-Cancer Drugs 19(2):183-8 · March 2008 with 339 Reads
https://insights.ovid.com/crossref?an=00001813-200802000-00010
Reconstituted (synthetic) high-density lipoprotein particles carrying paclitaxel (rHDL/PTX) were prepared with substantially higher PTX content than reported earlier. The rHDL/PTX complexes seemed to be primarily spherical nanoparticles when examined via electron microscopy, with a constant composition, molecular weight and exceptional stability even after ultracentrifugation and storage for …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125756/
The purpose of this study was to develop a novel synthetic high-density lipoprotein (sHDL) nanoparticle delivery system for 10-hydroxycamptothecin (HCPT) for treatment of colon carcinoma. HDL is recognized by scavenger receptor B-I (SR-BI) over-expressed in colon carcinomas 5- to 35-fold relative to the human fibroblasts.Author: Yue Yuan, Yue Yuan, Jian Wen, Jie Tang, Qiming Kan, Rose Ackermann, Karl Olsen, Anna Schwendeman
https://www.sciencedirect.com/science/article/pii/S1549963416300569
High-density lipoprotein (HDL) is a family of 7-12 nanometer sized particles comprised of apolipoproteins and lipids 1 that function, among other things, as a transport system for a variety of hydrophobic bio-molecules in vertebrates and insects.Author: Jens Bæk Simonsen
https://www.sciencedirect.com/science/article/pii/S0304383510003125
It has been shown that high density lipoprotein (HDL) or recombinant HDL (rHDL) reconstituted with wide-type apolipoprotein AI (apoAIwt) is an effective drug delivery model because of its specific structural characteristics and the targeted receptor-mediated uptake mechanism.Author: Xinbo Zhang, Baosheng Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196266/
Oct 15, 2018 · Our laboratory has been engaged in reconstituted high-density lipoproteins (rHDL) drug delivery research for more than a decade, focusing on formulating and evaluating rHDL drug delivery vehicles for a multitude of anti-cancer agents. Lipoprotein drug transporters have traditionally been used to deliver hydrophobic and amphiphilic drugs.Author: Sangram Raut, Linda Mooberry, Nirupama Sabnis, Ashwini Garud, Akpedje Serena Dossou, Andras Lacko
https://core.ac.uk/display/8688015
Validation of the reconstituted high-density lipoprotein (rHDL) drug delivery platform using dilauryl fluorescein (DLF). Drug Deliv and Transl Res.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620406/
Oct 26, 2015 · Synthetic/Reconstituted HDL as a Drug Delivery Vehicle Because of the concerns about infectious agents and the reproducibility of samples of human plasma HDL, its use for drug delivery in a clinical setting seems impractical.Author: Andras G. Lacko, Nirupama A. Sabnis, Bhavani Nagarajan, Walter J. McConathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397116/
Although synthetic reconstituted lipoproteins extended the feasibility of lipoprotein delivery vehicles, the use of recombinant ApoB-100 or Apo-AI is still limited by the significant effort and time required for manufacturing relevant amounts of apolipoproteins, including the removal of the tag from the recombinant protein and performance of ...Author: Huang Huang, William Cruz, Juan Chen, Gang Zheng, Gang Zheng
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