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https://www.sciencedirect.com/science/article/pii/S0264410X05010157
Immunization to the model antigen ovalbumin was investigated using a novel intracutaneous delivery system consisting of antigen-coated microneedle arrays. The influence of the following parameters on the resulting immune responses was investigated: depth of vaccine delivery, dose of vaccine delivered, density of microneedles on the array, and area of application.Author: Georg Widera, Juanita Johnson, Lomi Kim, Luz Libiran, Kofi Nyam, Peter E. Daddona, Michel Cormier
https://www.researchgate.net/publication/7521151_Effect_of_delivery_parameters_on_immunization_to_ovalbumin_following_intracutaneous_administration_by_a_coated_microneedle_array_patch_system
Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system Article in Vaccine 24(10):1653-64 · April 2006 with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285395/
Jan 31, 2017 · Consequently, the effect of vaccine nanoparticle parameters, such as size, on immune responses is complex and model-system-dependent. On a system-wide level, vaccine targeting to the draining lymph nodes is a strategy for enhancing antigen delivery to dendritic cells( 26 ), and 100-200 nm has been found to be the upper limit on nanoparticle size for passive drainage to the lymphatic …Author: Timothy Z. Chang, Samantha S. Stadmiller, Erika Staskevicius, Julie A. Champion
https://www.sciencedirect.com/science/article/pii/S0928098714003133
Finally, the effect of multiple parameters on the ovalbumin-specific-immune responses was investigated. This study shows that antigen-specific IgG responses are dependent on the usage of an impact-insertion applicator, the microneedle application area, and the site of microneedle application.Author: Koen van der Maaden, Eleni Maria Varypataki, Huixin Yu, Stefan Romeijn, Wim Jiskoot, Joke Bouwstra
https://www.zosanopharma.com/technology/publications/
Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system Georg Widera, Juanita Johnson, Lomi Kim, Luz Libiran, Kofi Nyam, Peter E. Daddona, Michel Cormier. Vaccine 24, 1653-1664, 2006. Transdermal delivery of desmopressin using a coated microneedle array patch system
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917494/
Effectiveness of influenza vaccination is limited by quality and breadth of the immune response and time required for vaccine delivery1. Traditional intramuscular (IM) injection requires hypodermic needles that cause needle phobia and generate biohazardous waste.Author: Sean P Sullivan, Dimitrios G Koutsonanos, Maria del Pilar Martin, Jeong Woo Lee, Vladimir Zarnitsyn,...
https://www.ncbi.nlm.nih.gov/pubmed/27918020
Jan 31, 2017 · Nanoparticle vaccine delivery platforms are a promising technology for enhancing vaccine immunogenicity. Protein nanoparticles (PNPs), made entirely from antigen, have been shown to induce protective immune responses against influenza. However, the fundamental mechanisms by which PNPs enhance component protein immunogenicity are not understood.Author: Timothy Z. Chang, Samantha S. Stadmiller, Erika Staskevicius, Julie A. Champion
https://www.researchgate.net/publication/325415975_Development_of_PLGA_nanoparticle_loaded_dissolving_microneedles_and_comparison_with_hollow_microneedles_in_intradermal_vaccine_delivery
The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin.
https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20and%20Parameters/Advers-reactions-to-vaccines-2012.pdf
amounts of ovalbumin. Neither skin testing with the vaccine nor dividing the dose is required; however, the vaccine should be administered in a setting in which anaphylaxis can be recog-nized and treated. EXECUTIVE SUMMARY Mild local reactions and constitutional symptoms, such as fever, after vaccinations are common and do not contraindicate future doses.
https://www.researchgate.net/publication/313325201_Enhancement_of_Skin_Permeation_and_Skin_Immunization_of_Ovalbumin_Antigen_via_Microneedles
Enhancement of Skin Permeation and Skin Immunization of Ovalbumin Antigen via Microneedles Article in AAPS PharmSciTech 18(7) · February 2017 with 13 Reads How we measure 'reads'
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