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https://www.sciencedirect.com/science/article/pii/S093964110000120X
A new oral erosion controlled drug delivery system on the basis of polyvinyl alcohols with a late burst in the release profile is developed. This late burst occurs after addition of sparingly soluble substances, either excipients like carboxylic acids and neutral cellulose or drugs like theophylline and theobromine.Author: Oliver L. Freichel, Bernhard C. Lippold
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261190/
Sep 28, 2014 · Drug release from PLGAs can have multiple phases, which typically include (a) an initial burst phase lasting over one to several days or even a week, (b) a lag (or induction) phase where low levels of polymer erode and sometimes little or no drug release is observed, and (c) an active erosion phase, where polymer mass is continuously lost from the polymer and drug release becomes …Author: Steven P. Schwendeman, Ronak B. Shah, Brittany A. Bailey, Anna S. Schwendeman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518665/
Jan 10, 2013 · Mechanistic models for erosion-controlled drug delivery systems often are sorted into two categories : discrete stochastic models and continuum-scale deterministic models. The first category considers erosion as a random process using Monte Carlo simulations and cellular automata, while the second treats the overall polymer erosion process as a combination of transport and …Author: Ashlee N. Ford Versypt, Ashlee N. Ford Versypt, Daniel W. Pack, Daniel W. Pack, Richard D. Braatz, R...
https://www.sciencedirect.com/topics/medicine-and-dentistry/controlled-drug-release
In temporal control, the aim of the drug delivery system is to deliver the drug over an extended period of time or at a specific duration during treatment. This type of control is highly beneficial for drugs having fast metabolism and elimination after administration. In distribution control, the aim of the drug delivery system is to target the release of the drug to the precise site of activity within the body.
https://web.mit.edu/braatzgroup/mathematical_modeling_of_drug_delivery_from_autocatalytically_degradable_plga_microspheres_a_review.pdf
erosion-controlled systems (release as a result of degradation and ero-sion of polymers). For biodegradable polyesters such as PLGA, drug re-lease occurs through a combination of degradation and erosion of polymer and transport of drug and is classified as being erosion-controlled. In this section we overview the mechanisms of each of
https://www.sciencedirect.com/science/article/pii/S0169409X01001168
Due to the significant chemical and physicochemical differences among individual bioerodible polymers used for controlled drug delivery systems, various mathematical models have been developed to describe the chemical reactions and physical mass transport processes involved in erosion-controlled drug release.Author: J. Siepmann, A. Göpferich
https://www.researchgate.net/publication/326225259_MICROSPHERES_AS_CONTROLLED_DRUG_DELIVERY_SYSTEM_AN_UPDATED_REVIEW
Controlled or modified drug delivery systems offer numerous advantages of delivering a drug to the body in a précised manner with an aim to minimize its unwanted side effects and maximize its ...
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future.
https://www.slideshare.net/NikitaNikam8/rate-controlled-drug-delivery-system-127500706
Jan 08, 2019 · Mechanically activated drug delivery systems In this type of activation-controlled drug delivery system the drug reservoir is a solution formulation retained in a container equipped with mechanically activated pumping system. • The volume of solution delivered is controllable …
https://www.youtube.com/watch?v=UfChh_EBSVY
Jun 25, 2016 · Nanoscience and drug delivery -- small particles for big problems Taylor Mabe ... Novel Drug Delivery System by Dr Abdul Bari Mohd - Duration: 36:40. Dr Bari 15,536 views.
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