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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044603/
Sep 28, 2010 · For polymeric plasmid delivery, to improve the efficiency of intracellular delivery and release of the nucleic acid (DNA or siRNA), ternary complexes composed of nucleic acid, polycations, and a charge-reversal polymer were developed.Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/enhanced-sirna-delivery-and-long-term-gene-silencing.html
Figure 1. Gene Silencing After Retroviral Delivery of siRNA. Retroviral vectors expressing the indicated siRNA inserts from either the H1 or U6 promoter were transfected into a retrovirus packaging cell line in 6 well plates. Three days following infection, virus was collected and used to …
https://pubs.acs.org/doi/abs/10.1021/nn101638u
Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte. Abstract. Charge-reversal functional gold nanoparticles first prepared by layer-by-layer technique were employed to deliver small interfering RNA (siRNA) and plasmid DNA into cancer cells.Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://pubs.acs.org/doi/pdfplus/10.1021/nn101638u
Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte Shutao Guo † ‡ ⊥ , Yuanyu Huang § ⊥ , Qiao Jiang † , Yun Sun † , Liandong Deng ‡ , Zicai Liang § , Quan Du § , Jinfeng Xing ‡ , Yuliang Zhao † , …
https://www.ncbi.nlm.nih.gov/pubmed/20707386
Sep 28, 2010 · Polyacrylamide gel electrophoresis measurements of siRNA confirmed the occurrence of the charge-reversal property of functional gold nanoparticles. The expression efficiency of enhanced green fluorescent protein (EGFP) was improved by adjuvant transfection with charge-reversal functional gold nanoparticles, which also had much lower toxicity to cell proliferation.Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://briefs.techconnect.org/wp-content/volumes/Nanotech2008v2/pdf/1381.pdf
In this report, we present many delivery systems enhancing siRNA delivery. Non-viral vectors offer appealing alternatives to viruses for nucleic acid delivery in animals. In particular, the cationic linear polyethylenimine (PEI) is the most widely used vector for in vivo gene delivery [5].Author: P. Neuberg, J-P . Behr, P. Erbacher, Boulevard Sébastien Brandt
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391875/
Gene therapy is a therapeutic approach that aims to treat otherwise incurable diseases, like viral infections, hereditary disorders and cancer by replacing defective genes and the function of aberrant proteins, through gene incorporation in plasmids or viral vectors for nuclear delivery . Non-viral systems are however widely preferred, in order to reduce cellular toxicity, risk of casual gene insertion in the …Author: Elena Nicolì, Elena Nicolì, Marie Isabel Syga, Michela Bosetti, V. Prasad Shastri
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307782/
Dec 28, 2013 · We found that inclusion of oleic acid (OA), an unsaturated fatty acid; into the LNP formulation significantly enhanced the delivery efficacy for siRNA and miRNA. For proof-of-concept, miR-122, a liver-specific microRNA associated with many liver diseases, was used as a model agent to demonstrate the hepatic delivery efficacy both in tumor cells and in animals.Author: Xinmei Wang, Bo Yu, Wei Ren, Xiaokui Mo, Chenguang Zhou, Hongyan He, HuLiang Jia, Lu Wang, Samson T....
https://www.pnas.org/content/115/12/E2696
Mar 20, 2018 · To demonstrate that enhanced gene silencing can be achieved by delivery of siRNA/Ago2 complexes, we first used commercial polymer or lipid-based transfection reagents designed for in vitro use to examine the impact of preassembly of the complex versus siRNA alone.Author: Jiahe Li, Connie Wu, Wade Wang, Yanpu He, Elad Elkayam, Elad Elkayam, Leemor Joshua-Tor, Leemor Josh...
https://www.pnas.org/content/pnas/115/12/E2696.full.pdf
of siRNA/Ago2, which is critical for Ago2-mediated enhance- ment of gene silencing. The mRNA Cleavage Activity of Ago2 Is Primarily Responsible for Enhanced Gene Silencing. Among the four Ago members in mammalian cells, only Ago2 is able to cleave target mRNA (33).Author: Jiahe Li, Connie Wu, Wade Wang, Yanpu He, Elad Elkayam, Elad Elkayam, Leemor Joshua-Tor, Leemor Josh...
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