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https://www.ncbi.nlm.nih.gov/pubmed/14759812
Flexible alteration of virus surface properties would be beneficial for enhanced and targeted gene delivery. A useful approach could be based on a high-affinity receptor-ligand pair, such as avidin and biotin. In this study, we have constructed an avidin-displaying baculovirus, Baavi.Author: Jani K Räty, Kari J Airenne, Ari T Marttila, Varpu Marjomäki, Vesa P Hytönen, Pauliina Lehtolainen, ...
https://www.sciencedirect.com/science/article/pii/S1525001603003654
To improve baculovirus properties as a gene delivery vector, we fused avidin to the N-terminus of the baculovirus major envelope glycoprotein gp64 by genetic means. Baculovirus is unable to propagate in insect cells, if the natural gp64 is deleted.Author: Jani K Räty, Kari J Airenne, Ari T Marttila, Varpu Marjomäki, Vesa P Hytönen, Pauliina Lehtolainen, ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(03)00365-4
Flexible alteration of virus surface properties would be beneficial for enhanced and targeted gene delivery. A useful approach could be based on a high-affinity receptor–ligand pair, such as avidin and biotin. In this study, we have constructed an avidin-displaying baculovirus, Baavi. Avidin display was expected to enhance cell transduction due to the high positive charge of avidin in ...Author: Jani K Räty, Kari J Airenne, Ari T Marttila, Varpu Marjomäki, Vesa P Hytönen, Pauliina Lehtolainen, ...
https://www.researchgate.net/publication/8888592_Enhanced_Gene_Delivery_by_Avidin-Displaying_Baculovirus
Flexible alteration of virus surface properties would be beneficial for enhanced and targeted gene delivery. A useful approach could be based on a high-affinity receptor-ligand pair, such as ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488948/
To date, only avidin-displaying baculovirus has been shown to mediate both targeted and enhanced transduction to biotinylated mammalian cells . Generation of envelope-modified baculovirus vectors therefore enables new applications of the system, including targeted in vivo and ex …Author: Anna R. Mäkelä, Heli Matilainen, Daniel J. White, Erkki Ruoslahti, Christian Oker-Blom
https://www.researchgate.net/profile/Jani_Raety/publication/42426238_Baculovirus_surface_modifications_for_enhanced_gene_delivery_and_biodistribution_imaging_Bakulovirusten_pintaproteiinien_muokkaaminen_geeniterapian_tehostamista_ja_kulkeutumisen_kuvantamista_varten/links/0fcfd508a6fe83c404000000.pdf?origin=publication_detail
Baculovirus Surface Modifications for Enhanced Gene Delivery and Biodistribution Imaging Doctoral dissertation To be presented by permission of the Faculty of Natural and Environmental Sciences of ...
https://www.sciencedirect.com/science/article/pii/S0042682209000993
Baculovirus, containing an appropriate eukaryotic promoter, is considered an attractive approach for an efficient and safe gene delivery vehicle. However, the drawbacks of baculovirus, such as the lack of specificity and the inactivation of baculovirus by the complement system in human serum, negatively affect efficient gene delivery.Author: You-Kyoung Kim, Jae Young Choi, Hu-Lin Jiang, Rohidas Arote, Dhananjay Jere, Myung-Haing Cho, Yeon H...
https://www.nature.com/articles/s41551-018-0318-7
Nov 12, 2018 · CRISPR–Cas9-mediated genome editing can be activated locally in vivo via an applied magnetic field, after complexation of magnetic nanoparticles with …Author: Haibao Zhu, Linlin Zhang, Sheng Tong, Ciaran M. Lee, Harshavardhan Deshmukh, Gang Bao
https://www.nature.com/articles/3302934
Apr 05, 2007 · We have previously reported the construction of a novel avidin-displaying baculovirus (Baavi) with enhanced transduction efficiency in vitro 16 and showed it to be suitable for viral particle ...Author: J K Räty, T Liimatainen, T Huhtala, M U Kaikkonen, K J Airenne, J M Hakumäki, A Närvänen, S Ylä-Hert...
http://www.eurekaselect.com/79314
An interesting new exploitation for avidin-biotin techniques is the utilization of this strong affinity in gene therapy, to target and enhance gene delivery to the appropriate target cells and tissues. In this communication, we review novel avidin fusion proteins that have been developed for enhanced gene delivery and drug targeting purposes.Author: Olli H. Laitinen, Kari J. Airenne, Jani K. Raty, Thomas Wirth, Seppo Yla-Herttuala
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