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https://pubs.acs.org/doi/abs/10.1021/nn101638u
Enhanced siRNA Delivery and Silencing Gold–Chitosan Nanosystem with Surface Charge-Reversal Polymer Assembly and Good Biocompatibility. ACS Nano 2012, 6 (8) , 7340-7351. DOI: 10.1021/nn3024688. Li-Chih Hu, Yusuke Yonamine, Shih-Hui Lee, …Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044603/
Sep 28, 2010 · Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte. ... Among them, PEI is the gold standard for gene delivery, which has strong escape capacity from endosome due to “proton sponge” effect. In the past, a lot of work had been done on improving the gene transfection efficiency based ...Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://www.ncbi.nlm.nih.gov/pubmed/20707386
Sep 28, 2010 · Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. Guo S(1), Huang Y, Jiang Q, Sun Y, Deng L, Liang Z, Du Q, Xing J, Zhao Y, Wang PC, Dong A, Liang XJ.Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://pubs.acs.org/doi/full/10.1021/nn101638u
Charge-reversal functional gold nanoparticles first prepared by layer-by-layer technique were employed to deliver small interfering RNA (siRNA) and plasmid DNA into cancer cells. Polyacrylamide gel electrophoresis measurements of siRNA confirmed the occurrence of the charge-reversal property of functional gold nanoparticles. The expression efficiency of enhanced green fluorescent protein (EGFP ...Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://www.researchgate.net/publication/45648173_Enhanced_Gene_Delivery_and_siRNA_Silencing_by_Gold_Nanoparticles_Coated_with_Charge-Reversal_Polyelectrolyte
For example, enhanced gene delivery and siRNA silencing by gold nanostructures coated with positively charged molecules were readily achieved in either in vitro or in vivo studies [17][18] [19 ...
https://www.sciencedirect.com/science/article/pii/S1525001616306967
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies.Author: Ya Ding, Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent ...
https://www.researchgate.net/publication/323434074_Enhanced_Delivery_of_Therapeutic_siRNA_into_Glioblastoma_Cells_Using_Dendrimer-Entrapped_Gold_Nanoparticles_Conjugated_with_b-Cyclodextrin
with the siRNA, and enables enhanced gene silencing to inhibit the expression of Bcl-2 and VEGF. ... delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors. Biomaterials.
https://www.pnas.org/content/pnas/106/14/5546.full.pdf
Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons Adela C. Bonoiua,1, Supriya D. Mahajanb,1, Hong Dinga, Indrajit Roya, Ken-Tye Yonga, Rajiv Kumara, Rui Hua, Earl J. Bergeya, Stanley A. Schwartzb, and Paras N. Prasada,2 aInstitute for Lasers Photonics and Biophotonics, The State University of New York ...Author: Adela C. Bonoiu, Supriya D. Mahajan, Hong Ding, Indrajit Roy, Ken-Tye Yong, Rajiv Kumar, Rui Hu, Ear...
https://www.pnas.org/content/106/14/5546
Apr 07, 2009 · Drug abuse is a worldwide health concern in which addiction involves activation of the dopaminergic signaling pathway in the brain. Here, we introduce a nanotechnology approach that utilizes gold nanorod-DARPP-32 siRNA complexes (nanoplexes) that target this dopaminergic signaling pathway in the brain. The shift in the localized longitudinal plasmon resonance peak of gold nanorods (GNRs) …Author: Adela C. Bonoiu, Supriya D. Mahajan, Hong Ding, Indrajit Roy, Ken-Tye Yong, Rajiv Kumar, Rui Hu, Ear...
https://www.nature.com/articles/ncomms15130
Apr 25, 2017 · Here we show that gold nanocluster-assisted delivery of siRNA of NGF (GNC–siRNA) allows efficient NGF gene silencing and pancreatic cancer treatment. ... GNC–siRNA complex enhanced …Author: Yifeng Lei, Yifeng Lei, Lixue Tang, Yangzhouyun Xie, Yunlei Xianyu, Lingmin Zhang, Peng Wang, Yoh Ha...
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