Enhanced Gene Delivery And Sirna Silencing By Gold Nanoparticles

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Enhanced Gene Delivery and siRNA Silencing by Gold ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044603/
    Sep 28, 2010 · Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte. ... However, the release extent of siRNA in cellular cytoplasm was low, due to the high binding ability between the gold nanoparticles and siRNA. Therefore, to achieve the same knockdown efficacy of gene expression with the PEI/siRNA ...Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...

Enhanced Gene Delivery and siRNA Silencing by Gold ...

    https://pubs.acs.org/doi/abs/10.1021/nn101638u
    Charge-reversal functional gold nanoparticles first prepared by layer-by-layer technique were employed to deliver small interfering RNA (siRNA) and plasmid DNA into cancer cells. Polyacrylamide gel electrophoresis measurements of siRNA confirmed the occurrence of the charge-reversal property of functional gold nanoparticles. The expression efficiency of enhanced green fluorescent protein (EGFP ...Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...

Enhanced gene delivery and siRNA silencing by gold ...

    https://www.ncbi.nlm.nih.gov/pubmed/20707386
    Sep 28, 2010 · Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. Guo S(1), Huang Y, Jiang Q, Sun Y, Deng L, Liang Z, Du Q, Xing J, Zhao Y, Wang PC, Dong A, Liang XJ.Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...

Enhanced Gene Delivery and siRNA Silencing by Gold ...

    https://www.researchgate.net/publication/45648173_Enhanced_Gene_Delivery_and_siRNA_Silencing_by_Gold_Nanoparticles_Coated_with_Charge-Reversal_Polyelectrolyte
    Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte Article in ACS Nano 4(9):5505-11 · September 2010 with …

Gold Nanoparticles for Nucleic Acid Delivery - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S1525001616306967
    Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies.Author: Ya Ding, Ya Ding, Ziwen Jiang, Krishnendu Saha, Chang Soo Kim, Sung Tae Kim, Ryan F Landis, Vincent ...

Nanoparticles Escaping RES and Endosome: Challenges for ...

    https://www.hindawi.com/journals/jnm/2011/742895/
    Small interfering RNAs (siRNAs) technology has emerged as a promising potential treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential of siRNA, there are challenges for developing efficient and specific delivery systems for systemic administration. There are extracellular and intracellular barriers for nanoparticle-mediated delivery. First, nanoparticles ...Author: Shutao Guo, Leaf Huang

Gold Nanoparticle - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/chemistry/gold-nanoparticle
    Goldie oza, ... Subramaniam Velumani, in Engineering of Nanobiomaterials, 2016. 14.4.1.2 Delivery of siRNA/DNA. Gold nanoparticles are considered to be an efficient system for delivery of either DNA or RNA for gene silencing and consequently for therapeutic purposes. Mirkin et al. demonstrated that a dense layer of ssDNA molecules can coat the surface of citrate stabilized spherical ...

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