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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108588/
Enhanced Gene and siRNA Delivery by Polycation-Modified Mesoporous Silica Nanoparticles Loaded with Chloroquine Shanta Raj Bhattarai , Elayaraja Muthuswamy , Amit Wani , Michal Brichacek , Antonio L. Castañeda , Stephanie L. Brock , and David OupickyAuthor: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://www.ncbi.nlm.nih.gov/pubmed/20730557
Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine. Bhattarai SR(1), Muthuswamy E, Wani A, Brichacek M, Castañeda AL, Brock SL, Oupicky D. Author information: (1)Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, USA.Author: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://link.springer.com/10.1007/s11095-010-0245-0
Aug 21, 2010 · The biological studies show that polycation-modified MSN are able to simultaneously deliver CQ with DNA and siRNA. The co-delivery of CQ and the nucleic acids leads to a significantly increased transfection and silencing activity of the complexes compared with MSN not loaded with CQ.Author: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://www.researchgate.net/publication/45800974_Enhanced_Gene_and_siRNA_Delivery_by_Polycation-Modified_Mesoporous_Silica_Nanoparticles_Loaded_with_Chloroquine
Enhanced Gene and siRNA Delivery by Polycation-Modified Mesoporous Silica Nanoparticles Loaded with Chloroquine
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30207-0
Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a frequent long-term treatment regimen, whereas topical delivery of siRNA to the cornea is hampered by the eye surface’s protective mechanisms.Author: Davide Schiroli, María José Gómara, Eleonora Maurizi, Sarah D. Atkinson, Laura C. Mairs, Kathleen A....
https://academic.oup.com/nar/article/48/1/75/5644999
Nov 28, 2019 · Even in the absence of a transfection reagent, internally-modified folic acid–siRNAs aL-F1 and aL-F2 still displayed enhanced gene-silencing potency and much lower IC 50 values than aL-F3 (modified at position 5 from sense strand 3′ end) and aL-F4 (modified at the 3′ end). We only observed 40–65% knockdown after 0.75 μM treatment of aL-F3 and aL-F4.Author: Lidya Salim, Golam Islam, Jean-Paul Desaulniers
https://www.thermofisher.com/jp/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/enhanced-sirna-delivery-and-long-term-gene-silencing.html
Figure 1. Gene Silencing After Retroviral Delivery of siRNA. Retroviral vectors expressing the indicated siRNA inserts from either the H1 or U6 promoter were transfected into a retrovirus packaging cell line in 6 well plates. Three days following infection, …
https://pubs.acs.org/doi/abs/10.1021/nn101638u
Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-Reversal Polyelectrolyte. Abstract. Charge-reversal functional gold nanoparticles first prepared by layer-by-layer technique were employed to deliver small interfering RNA (siRNA) and plasmid DNA into cancer cells.Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://www.sciencedirect.com/science/article/pii/S0378517313003256
Jun 25, 2013 · Small interfering RNA (siRNA), a class of double-stranded RNA molecules that are approximately 20–25 nucleic acids long, is a powerful tool for gene knockdown in biology research, especially in the analysis of gene function.Author: Gaoyang Guo, Gaoyang Guo, Li Zhou, Li Zhou, Zhifei Chen, Weilin Chi, Xiuqun Yang, Wei Wang, Wei Wang...
https://www.sciencedirect.com/science/article/pii/S1525001616308413
Through co-delivery of miRNA and siRNA in the LPH formulation, the combination strategy is effective to trigger an enhanced therapeutic effect. To our knowledge, it is the first study of systemic delivery of miRNA for cancer therapy by using a targeted gene delivery system.Author: Yunching Chen, Xiaodong Zhu, Xiaoju Zhang, Bin Liu, Leaf Huang
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