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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108588/
Mesoporous silica nanoparticles (MSN) are particularly promising delivery vectors for drug/gene and drug/siRNA combinations because of high drug-loading capacity and compatibility with a large number of conventional chemotherapeutic agents.Author: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://www.ncbi.nlm.nih.gov/pubmed/20730557
Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine. Bhattarai SR(1), Muthuswamy E, Wani A, Brichacek M, Castañeda AL, Brock SL, Oupicky D. Author information: (1)Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, USA.Author: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://link.springer.com/10.1007/s11095-010-0245-0
Aug 21, 2010 · To prepare mesoporous silica-based delivery systems capable of simultaneous delivery of drugs and nucleic acids. The surface of mesoporous silica nanoparti The particles were then loaded with a lysosomotropic agent chloroquine (CQ) and complexed with plasmid DNA or siRNA.Author: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://nebraska.pure.elsevier.com/en/publications/enhanced-gene-and-sirna-delivery-by-polycation-modified-mesoporou
Jan 01, 2010 · title = "Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine", abstract = "Purpose To prepare mesoporous silica-based delivery systems capable of simultaneous delivery of drugs and nucleic acids.Author: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://www.cabdirect.org/cabdirect/abstract/20113052594
Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine. Purpose - To prepare mesoporous silica-based delivery systems capable of simultaneous delivery of drugs and nucleic acids.Author: Shanta Raj Bhattarai, Elayaraja Muthuswamy, Amit Wani, Michal Brichacek, Antonio L. Castañeda, Steph...
https://www.researchgate.net/publication/45800974_Enhanced_Gene_and_siRNA_Delivery_by_Polycation-Modified_Mesoporous_Silica_Nanoparticles_Loaded_with_Chloroquine
Due to large surface area, tunable pore size, easy surface manipulation and low toxicity, mesoporous silica nanoparticles (MSNs) may act as a suitable vector for gene delivery.
https://www.researchgate.net/publication/322663867_Enhanced_gene_delivery_by_polyethyleneimine_coated_mesoporous_silica_nanoparticles
Mesoporous silica nanoparticles (MSNs) are one of the promising nanoparticles that enable the delivery of drugs and siRNA simultaneously. MSNs coated with copolymer that able for co-delivery …
https://www.sciencedirect.com/science/article/pii/S1818087617306426
Modified mesoporous silica nanoparticles (MSNs) where the pores are surface functionalized with polyethylene imine (PEI) and linkers containing intracellularly cleavable S S bonds, and a particle surface covered with pre-polymerized PEI were evaluated for their transfection efficiency in MDA-MB 231 breast cancer cells stably expressing GFP. PEI-coated siRNA/MSN complexes provide significantly more effective delivery of siRNAs …Author: Anna Slita, Anna Egorova, Eudald Casals, Anton Kiselev, Jessica M. Rosenholm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953950/
Jun 06, 2010 · Utilizing mesoporous silica nanoparticles (MSNs) as a delivery vehicle for siRNA represents a relatively new form of gene therapy.[8–10] MSNs have many advantages for intra-cellular delivery, such as large surface area, tunable pore sizes, easy modification of surface, and encapsulation of guest molecules such as drugs, proteins, and biogenic molecules.[16–18]Author: Christopher Hom, Jie Lu, Monty Liong, Hanzhi Luo, Zongxi Li, Jeffrey I. Zink, Fuyuhiko Tamanoi
http://onlinelibrary.wiley.com/doi/10.1002/adfm.201404629/abstract
May 11, 2015 · Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted ... Young Kee Shin, Eunah Kang, Seong Hoon Jeong, Polyamidoamine-Decorated Nanodiamonds as a Hybrid Gene Delivery Vector and siRNA Structural Characterization ... Bizhan Malaekeh-Nikouei, Codelivery of anticancer drugs and siRNA by mesoporous silica nanoparticles ...
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