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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835414/
Apr 18, 2016 · The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy. Mei-Xia Zhao and ... from the endosome after entering cells and how to retain aptamer targeting specificity when chimeras are combined with delivery carriers. Since both siRNA and aptamer are RNA molecules and often share similar ...Author: Mei-Xia Zhao, Bing-Jie Zhu
https://www.nature.com/articles/s41551-018-0214-1
Hurdles in cell-specific delivery of small interfering RNA (siRNA) in vivo hinder the clinical translation of RNA interference (RNAi). A fundamental problem concerns conflicting requirements for ...Author: Wanyi Tai, Junwei Li, Eva Corey, Xiaohu Gao
https://pubs.acs.org/doi/abs/10.1021/acsnano.7b08777
The delivery of small interfering RNA (siRNA) remains a major hurdle for the clinical translation of RNA interference (RNAi) therapeutics. Because of its low valency and rigid nature, siRNA typically requires high excesses of cationic delivery materials to package it stably and deliver it to the cytoplasm of target cells, resulting in high toxicities and inefficient gene silencing in vivo. To ...Author: Connie Wu, Jiahe Li, Wade Wang, Paula T. Hammond
https://www.ncbi.nlm.nih.gov/pubmed/25133608
Sep 23, 2014 · (1)Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo , Tokyo 113-8656, Japan. For systemic delivery of siRNA to solid tumors, a size-regulated and reversibly stabilized nanoarchitecture was constructed by using a 20 kDa siRNA-loaded unimer polyion complex (uPIC) and 20 nm gold nanoparticle (AuNP).Author: Hyun Jin Kim, Hiroyasu Takemoto, Yu Yi, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi,...
https://www.researchgate.net/publication/336161535_Rekindling_RNAi_Therapy_Materials_Design_Requirements_for_In_Vivo_siRNA_Delivery
nano particle-based carrier systems for siRNA delivery, F igure 5 shows a generalized schematic of each carrier type to be dis- cussed, with representative electron micrograph images.
https://www.researchgate.net/publication/50273219_Engineering_Nanocarriers_for_siRNA_Delivery
Engineering Nanocarriers for siRNA Delivery. ... cellular uptake of siRNA carriers occurs via endocytosis ( Lu et al., 2009), which means that for siRNA to reach the RNAi enzymatic machinery it ...
https://www.sciencedirect.com/science/article/pii/S0734975014000949
Nano carriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers. ... -PAMAM-D-PEG-DOPE, and PEG-DOPE carriers. The co-delivery of FAM-siRNA and doxorubicin was analyzed flow cytometry; G(4)-PAMAM-D-PEG-DOPE micelles showed better delivery of siRNA (i.e., a higher silencing effect) than the mixed ...Author: Vasilios Tsouris, Min Kyung Joo, Sun Hwa Kim, Ick Chan Kwon, Ick Chan Kwon, You Yeon Won, You Yeon W...
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201903637
3 Protective Carriers for siRNA Delivery. As opposed to restriction enzyme‐based tools that require the delivery of multiple payloads (e.g., enzyme, guide nucleotide sequence, and DNA fragments for gene insertion), RNAi therapeutics present a simpler and more feasible payload for genetic modification, as they are singular anionic ...Author: Byungji Kim, Ji‐Ho Park, Michael J. Sailor
https://www.nature.com/articles/s41551-018-0240-z
May 10, 2018 · Efficient siRNA delivery with non-cationic carriers. ... Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong ... Nano Letters (2020)Author: Chun Kit K. Choi, Lei Zhang, Chung Hang Jonathan Choi
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