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https://www.sciencedirect.com/science/article/pii/S0014488607003305
Our strategy for delivery of GDNF to the striatum in PD patients is to use encapsulated cell biodelivery (ECB). The cell encapsulation aims primarily at providing a physical barrier to prevent immune rejection and direct host contact with the allogeneic, genetically modified therapeutic cells after transplantation, and to allow for the removal of the GDNF-producing cells if untoward effects occur.Author: Olle Lindvall, Lars U. Wahlberg
https://www.nature.com/articles/gt2011178
Nov 24, 2011 · We have previously described an encapsulated cell biodelivery device, NsG0202, capable of local delivery of NGF by a genetically modified human cell line, NGC-0295.Author: L Fjord-Larsen, P Kusk, D F Emerich, C Thanos, M Torp, B Bintz, J Tornøe, A H Johnsen, L U Wahlberg
https://www.ncbi.nlm.nih.gov/pubmed/22377499/
Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease. Eriksdotter-Jönhagen M(1), Linderoth B, Lind G, Aladellie L, Almkvist O, Andreasen N, Blennow K, Bogdanovic N, Jelic V, Kadir A, Nordberg A, Sundström E, Wahlund LO, Wall A, Wiberg M, Winblad B, Seiger A, Almqvist P, Wahlberg L.Author: Maria Eriksdotter-Jönhagen, Bengt Linderoth, Goran Lind, Layth Aladellie, Ove Almkvist, Niels Andrea...
https://clinicaltrials.gov/ct2/show/NCT01163825
The objective of encapsulated cell biodelivery (ECB) is to maintain normal levels of NGF to support cholinergic function. NsGene's NGF secreting ECB device (NsG0202) combines the potential benefits of targeted gene therapy with the safety of a retrievable implantable device.
https://www.michaeljfox.org/grant/pre-clinical-development-encapsulated-cell-biodelivery-gdnf-parkinsons-disease
Pre-clinical Development of Encapsulated Cell Biodelivery of GDNF for Parkinson's Disease Objective/Rationale: Glial cell line-derived neurotrophic factor (GDNF) is a protein that can aid in survival of the dopamine cells that die in Parkinson’s disease (PD).
https://www.researchgate.net/publication/221873215_Encapsulated_Cell_Biodelivery_of_Nerve_Growth_Factor_to_the_Basal_Forebrain_in_Patients_with_Alzheimer's_Disease
Encapsulated Cell Biodelivery of Nerve Growth Factor to the Basal Forebrain in Patients with Alzheimer's Disease Article (PDF Available) in Dementia and Geriatric Cognitive Disorders 33(1):18-28 ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)30911-X.pdf
Encapsulated cell (EC) biodelivery is an attractive alternative to more direct gene therapy methods and combines the potency of gene therapy with that of an implantable and retrievable device. 13 Within the tip of this implant, a stably genetically engineered
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30911-X
Dec 01, 2010 · Encapsulated cell (EC) biodelivery is an attractive alternative to more direct gene therapy methods and combines the potency of gene therapy with that of …Author: Lone Fjord-Larsen, Philip Kusk, Jens Tornøe, Bengt Juliusson, Malene Torp, Carsten R Bjarkam, Mette ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997581/
Encapsulated cell (EC) biodelivery is an attractive alternative to more direct gene therapy methods and combines the potency of gene therapy with that of an implantable and retrievable device. 13 Within the tip of this implant, a stably genetically engineered human cell line grows on a polymer scaffold behind a semipermeable hollow fiber membrane and continuously secretes a relatively low but potent dose of …Author: Lone Fjord-Larsen, Philip Kusk, Jens Tornøe, Bengt Juliusson, Malene Torp, Carsten R Bjarkam, Mette ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182013/
Step 4: Encapsulated cell biodelivery in TBI. According to the existing preclinical studies and the preliminary results of the ongoing clinical trial in ICH patients, GLP-1-secreting hMSC capsules might be an effective treatment for TBI patients as well.Author: Anna Heile, Thomas Brinker
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