Encapsulate Sirna Liposome Delivery

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Liposome Encapsulation Services: siRNA, miRNA, DNA ...

    http://altogenlabs.com/pre-clinical-research-services/liposome-encapsulation-services-sirna-mirna-dna-proteins/
    Liposomes are artificially manufactured vesicles, composite of phospholipid structures that can be made to encapsulate various types of molecules within the aqueous core of the liposome. Liposomes are used to efficiently deliver cargo molecules (such as siRNA, mRNA, DNA, RNA,...

Delivery of small-interfering RNA (siRNA) to the brain

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
    In contrast to the above-described non-invasive strategies for delivery of shRNA or siRNA to the CNS via receptor-mediated targeting or as liposome-based ‘payloads’, an alternative method (that can replace the cell- or tissue-specific ligands) is the use of CPP for targeting of siRNA [ 16, 26 ].Author: Saroj P Mathupala

siRNA Liposome Encapsulation Service Altogen Labs

    http://altogenlabs.com/rna-interference-rnai-services/sirna-liposome-encapsulation-service/
    siRNA Liposome Encapsulation Service Liposome Encapsulation of Small Interfering RNA (siRNA) Molecules Liposomes are composite structures made of phospholipids that are artificially made to encapsulate various types of nucleic acids within the aqueous core of the liposome.

In vivo Delivery of Liposomal Encapsulated Survivin siRNA ...

    https://cds.ismrm.org/protected/10MProceedings/files/2713_6047.pdf
    siRNA-Liposome Saline 0 50 100 150 200 250 300 350 400 450 0 1020 3040 5060 7080 Post Dose (hrs) Tumour Volume (mm3) Control siRNA-Liposome Survivin siRNA-Liposome In vivo Delivery of Liposomal Encapsulated Survivin siRNA Leads to a Reduction in Tumour Growth Rate G. D. Kenny1, T. L. Kalber1, N. Kamaly1,2, L. P. Brody1, A. D. Miller2, and J. D ...

VEGF siRNA delivered by polycation liposome-encapsulated ...

    https://www.ncbi.nlm.nih.gov/pubmed/28860767
    Aug 21, 2017 · In this study, we developed polycation liposome-encapsulated calcium phosphate nanoparticles (PLCP) for siRNA delivery in vivo. VEGF expression silencing effect in MCF-7 cells was investigated by real-time quantitative polymerase chain reaction and Western blot assay.Author: Jinliang Chen, Xiaoyi Sun, Rong Shao, Yichao Xu, Jianqing Gao, Wenquan Liang

CXCL1 gene silencing in skin using liposome-encapsulated ...

    https://www.sciencedirect.com/science/article/pii/S0168365914006087
    siRNA delivery into skin was approximated using a fluorescence-based assay to measure residual siRNA on microprojection arrays after in vivo application (Fig. 1B). A delivery efficiency of approximately 34% ± 17% of the coating formulation was estimated, corresponding to ~ 20 ng of liposome-encapsulated siRNA.Author: Oscar Haigh, Alexandra C.I. Depelsenaire, Stefano C. Meliga, Sally R. Yukiko, Nigel A.J. McMillan, I...

Liposomes and Lipid Nanoparticles as Delivery Vehicles for ...

    https://www.exeleadbiopharma.com/news/liposomes-and-lipid-nanoparticles-as-delivery-vehicles-for-personalized-medicine
    Nov 16, 2018 · LNPs are liposome-like structures especially geared towards encapsulating a broad variety of nucleic acids (RNA and DNA); and as such, they are the most popular non-viral gene delivery system. Exelead develops and manufactures LNPs to encapsulate different types of genetic payloads including siRNA, mRNA and saRNA.

VEGF siRNA delivered by polycation liposome-encapsulated ...

    https://www.dovepress.com/vegf-sirna-delivered-by-polycation--liposome-encapsulated-calcium-phos-peer-reviewed-article-IJN
    VEGF siRNA delivered by polycation liposome-encapsulated calcium phosphate nanoparticles for tumor angiogenesis inhibition in breast cancer. Abstract: Angiogenesis plays an important role in tumor development and metastasis, and many cancer cells upregulate VEGF expression to …Author: Jinliang Chen, Xiaoyi Sun, Rong Shao, Yichao Xu, Jianqing Gao, Wenquan Liang

Effect of surface properties on liposomal siRNA delivery ...

    https://www.sciencedirect.com/science/article/pii/S0142961215009667
    In general, there are four types of cationic liposomal carriers for siRNA delivery, which are monovalent cationic liposomes, pH-sensitive cationic liposomes, lipidoids, and multivalent cationic liposomes. It is worth noting that blood circulation of cationic liposomes is poor due to the positive surface charge,...Author: Yuqiong Xia, Jie Tian, Jie Tian, Xiaoyuan Chen

LIPOSOMAL SIRNA NANOCARRIERS FOR CANCER THERAPY

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527165/
    b. Obstacles for systemic use of siRNA-based therapeutics. The broad therapeutic applications of siRNA-based therapeutics in cancer are largely dependent on the development of rationally designed systemic delivery systems that can efficiently deliver the siRNA molecules into tumors and target cells (6, 7).The major limitations of the systemic use of siRNA-based therapies include rapid ...

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