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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167344/
Sep 28, 2014 · Recombinant functionalization of ELP unimers can alternatively be used as a tool to improve drug delivery as fusion with targeting or internalization peptides can enhance the accumulation or intracellular delivery of drug carriers at the disease site.Author: Sarah R. MacEwan, Ashutosh Chilkoti
https://chilkotilab.pratt.duke.edu/content/injectable-elp-depots-drug-delivery
Injectable ELP Depots for Drug Delivery We have several projects in the area of injectable drug delivery depots: (1) in a project on the intratumoral delivery of radionuclides, we have covalently conjugated radionuclides to an ELP with a transition temperature below body temperature and injected these conjugates directly into tumors.
https://www.ncbi.nlm.nih.gov/pubmed/20546809
Dec 30, 2010 · Thermally responsive elastin-like polypeptides (ELPs) are a promising class of recombinant biopolymers for the delivery of drugs and imaging agents to solid tumors via systemic or local administration.Author: Jonathan R. McDaniel, Daniel J. Callahan, Ashutosh Chilkoti
https://www.sciencedirect.com/science/article/pii/S0169409X10001110
Dec 30, 2010 · ELP–drug delivery strategies. This figure depicts four strategies that use ELPs to deliver drugs to a solid tumor in vivo. (A) Drug attachment triggered self-assembly of an ELP into micelles. Hydrophobic drugs are attached to the C-terminus of a hydrophilic ELP to trigger the self-assembly of micelles.Author: Jonathan R. McDaniel, Daniel J. Callahan, Ashutosh Chilkoti
https://www.physiology.org/doi/pdf/10.1152/ajprenal.00143.2016
kidney-targeted drug delivery. Elastin-like polypeptide (ELP) is a protein biopolymer com-posed of a repeating pentapeptide domain found in human elastin (51). ELP is advantageous as a drug carrier because its large size serves to stabilize small molecule drugs or peptide cargo from rapid clearance or degradation in vivo (5, 7, 37).Author: Gene L. Bidwell, Fakhri Mahdi, Qingmei Shao, Omar C. Logue, Jamarius P. Waller, Caleb Reese, Alejand...
https://www.sciencedirect.com/science/article/abs/pii/S0169409X02000418
In vivo fluorescent videomicroscopy and radiolabel distribution studies of ELP delivery to human tumors implanted in nude mice demonstrated that hyperthermic targeting of the thermally responsive ELP for 1 h provides a ∼two-fold increase in tumor localization compared to …Author: Ashutosh Chilkoti, Matthew R Dreher, Dan E Meyer, Drazen Raucher
https://www.tandfonline.com/doi/abs/10.1517/17425247.2015.974546
Expert opinion: ELP drug delivery technology is complementary and synergistic to current drug delivery modalities and based on existing hyperthermia technology. By using this technology to achieve chemotherapeutic targeting, efficacy can be improved and side effects reduced in comparison with current regimens, providing treatment alternatives and/or augmenting current therapies for cancer …Author: Jung Su Ryu, Drazen Raucher
https://journals.physiology.org/doi/full/10.1152/ajprenal.00143.2016
Given the presence of a free COOH-terminal thiol, KTP-ELP could easily be modified with a thiolated drug (such as captopril) to achieve kidney-specific delivery, or KTP-ELP could be used to deliver other small-molecule drugs engineered with thiol reactive cleavable linkers.Author: Gene L. Bidwell, Fakhri Mahdi, Qingmei Shao, Omar C. Logue, Jamarius P. Waller, Caleb Reese, Alejand...
https://www.nature.com/articles/s41598-018-24897-9
May 21, 2018 · ELPs have been utilized in the past two decades for tumor targeted drug delivery 5,25,29, for generation of slow-release subcutaneous drug depots 7,22,30, for ocular drug delivery …Author: Marija Kuna, Fakhri Mahdi, Alejandro R. Chade, Gene L. Bidwell
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