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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629443/
Aug 24, 2015 · Insoluble drug delivery technology utilizing the co-solvent-surfactant approach had indeed proved vital in providing an effective treatment option for cancer patients. Further improvement in the formulation of taxol׳s resulted in more patient compliance and new intellectual properties for pharmaceutical companies.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.sciencedirect.com/science/article/pii/S2211383515001069
Insoluble drug delivery technology utilizing the co-solvent-surfactant approach had indeed proved vital in providing an effective treatment option for cancer patients. Further improvement in the formulation of taxol׳s resulted in more patient compliance and new intellectual properties for pharmaceutical companies.Author: Sandeep Kalepu, Vijaykumar Nekkanti
http://www.pharmtech.com/dissolving-insoluble
May 02, 2008 · The formulation strategy section is followed by chapters that discuss powder technology, soft-gelatin capsule development, the development of oral modified-release delivery systems for insoluble compounds, and the scalable manufacture of water-insoluble drug products.
http://www.currentnanoscience.com/articles/168936/self-microemulsion-technology-for-water-insoluble-drug-delivery
In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs.
https://www.researchgate.net/publication/282246522_Insoluble_drug_delivery_strategies_Review_of_recent_advances_and_business_prospects
About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved.
https://www.chemistryworld.com/health-technology/dissolving-insoluble-drugs/3008720.article
Further, solid dispersion (a drug incorporated within a matrix, most often a water soluble polymer) spray-drying technology can be applied to the development of products from laboratory to commercial scale with a wide range of powder characteristics. 2,3. Creating an effective spray-dried dispersion (SDD) is a multi-step process.
http://www.veloxis.com/products-technology/our-technology/
MeltDose Drug Delivery Technology. MeltDose drug delivery technology is used to enhance the oral bioavailability and control the release of a drug, especially low water-soluble or water-insoluble drugs. Particle size plays a vital role in bioavailability.
https://www.pharmacircle.com/presentations/Water_Insoluble_Strategies.pdf
•Drug delivery provides measurable value Utilized in some capacity in 40% of Top 20 pharmaceutical products with sales of 51 billion USD worldwide. •Drug delivery increases revenues via patent protection and life cycle products Delays generic introduction in some cases and provides additional franchise revenues. •Drug delivery has to make sense
https://link.springer.com/article/10.1007%2Fs11051-019-4744-6
Jan 04, 2020 · Self-microemulsifying drug delivery system (SMEDDS) is a uniform and transparent solution consisting of oil phase, surfactant, co-surfactant, and a small amount of water. It could be orally administered under gastrointestinal peristalsis and spontaneously dispersed to form an oil-in-water microemulsion with typical particle sizes lower than 100 nm.Author: Beibei Yan, Yingying Ma, Juan Guo, Yancai Wang
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