Elp Drug Delivery Mass

We have collected information about Elp Drug Delivery Mass for you. Follow the links to find out details on Elp Drug Delivery Mass.


Applications of elastin-like polypeptides in drug delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167344/
    Sep 28, 2014 · Application of ELP depots for drug delivery in the joint has been explored by the thermal gelation of an ELP fusion with the anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra). The IL-1Ra ELP fusion retained bioactivity, although binding of the fusion protein to the IL-1 receptor was weaker than the binding of free IL-1Ra.Author: Sarah R. MacEwan, Ashutosh Chilkoti

Molecular Size Modulates Pharmacokinetics, Biodistribution ...

    https://www.nature.com/articles/s41598-018-24897-9
    May 21, 2018 · ELPs have been utilized in the past two decades for tumor targeted drug delivery 5,25,29, for generation of slow-release subcutaneous drug depots 7,22,30, for …Author: Marija Kuna, Fakhri Mahdi, Alejandro R. Chade, Gene L. Bidwell

Cell Penetrating Elastin-like Polypeptides for Therapeutic ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964383/
    Dec 30, 2010 · 2. The use of cell penetrating peptides for intracellular delivery of ELPs. The ELP drug carrier used for thermal targeting (ELP1) has a molecular weight of 59.1 kDa [], and it enters eukaryotic cells at low levels by an endocytic mechanism.In an attempt to improve the efficiency of cellular internalization of ELP, we modified it at its N-terminus with several CPPs (Figure 1A) [].Author: Gene L. Bidwell, Drazen Raucher

Injectable ELP Depots for Drug Delivery Chilkoti Group

    https://chilkotilab.pratt.duke.edu/content/injectable-elp-depots-drug-delivery
    We have several projects in the area of injectable drug delivery depots: (1) in a project on the intratumoral delivery of radionuclides, we have covalently conjugated radionuclides to an ELP with a transition temperature below body temperature and injected these conjugates directly into tumors.

Structural and Hydrodynamic Analysis of a Novel Drug ...

    https://www.cell.com/cms/10.1016/j.bpj.2013.03.040/attachment/cbd6b885-7bec-4398-af43-f0289027f8aa/mmc1.pdf
    Structural and Hydrodynamic Analysis of a Novel Drug Delivery Vector: ELP[V5G3A2-150] Daniel F. Lyons, † Vu Le,§ Gene L. Bidwell III,‡ Wolfgang H. Kramer,¶ Edwin A, Lewis, § Drazen Raucher,† and John J. Correia†* †Department of Biochemistry and ‡Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi; §Department of Chemistry, Mississippi State ...

Structural and Hydrodynamic Analysis of a Novel Drug ...

    https://www.sciencedirect.com/science/article/pii/S0006349513003792
    May 07, 2013 · Structural and Hydrodynamic Analysis of a Novel Drug Delivery Vector: ... and hydrodynamic properties of a specific ELP being investigated for drug delivery, ELP[V 5 G 3 A 2-150]. ... [V 5 G 3 A 2-150]) is a 758 residue polypeptide with a molecular mass of 59,546.61 Da . It is predicted by the software utility PONDR ...Author: Daniel F. Lyons, Vu Le, Gene L. Bidwell, Wolfgang H. Kramer, Edwin A. Lewis, Drazen Raucher, John J....

Thermal Cycling Enhances the Accumulation of a Temperature ...

    https://cancerres.aacrjournals.org/content/67/9/4418
    The delivery of anticancer therapeutics to solid tumors remains a critical problem in the treatment of cancer. This study reports a new methodology to target a temperature-responsive macromolecular drug carrier, an elastin-like polypeptide (ELP) to solid tumors. Using a dorsal skin fold window chamber model and intravital laser scanning confocal microscopy, we show that the ELP forms micron ...Author: Matthew R. Dreher, Wenge Liu, Charles R. Michelich, Mark W. Dewhirst, Ashutosh Chilkoti

Thermo-targeted drug delivery of geldanamycin to ...

    https://www.sciencedirect.com/science/article/pii/S0168365911005670
    Inverse phase transition is the key parameter to realize thermo-targeted drug delivery. It has been demonstrated that the thermal transition temperature (T t) of the ELP-homopolymer is affected by ELP length, concentration, and hydrophobicity . This generation of ELP-based diblock biopolymers is entirely unique with the addition of 15 ...Author: Y Chen, P Youn, DY Furgeson

Elastin-like polypeptides - Wikipedia

    https://en.wikipedia.org/wiki/Elastin_like_polypeptides
    Elastin-like polypeptides (ELPs) are synthesized biopolymers that have become an area of interest for their potentially practical benefits. They may hold key applications in the fields of cancer therapy, tissue scaffolding, and protein purification. For cancer therapy, research has suggested that manipulation of ELPs, through the addition of functional groups, can enable the ELP to conjugate ...

Purification of recombinant proteins by fusion with ...

    https://www.nature.com/articles/nbt1199_1112
    Nov 01, 1999 · We synthesized a gene encoding an ELP with guest residues Val, Ala, and Gly in the ratio 5:2:3 that had a predicted T t of approximately 40°C in water for a molecular mass (M r) greater than 50 ...Author: Dan E. Meyer, Ashutosh Chilkoti

Searching for Elp Drug Delivery Mass?

You can just click the links above. The data is collected for you.

Related Delivery Info