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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167344/
Sep 28, 2014 · Application of ELP depots for drug delivery in the joint has been explored by the thermal gelation of an ELP fusion with the anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra). The IL-1Ra ELP fusion retained bioactivity, although binding of the fusion protein to the IL-1 receptor was weaker than the binding of free IL-1Ra.Author: Sarah R. MacEwan, Ashutosh Chilkoti
https://www.nature.com/articles/s41598-018-24897-9
May 21, 2018 · ELPs have been utilized in the past two decades for tumor targeted drug delivery 5,25,29, for generation of slow-release subcutaneous drug depots 7,22,30, for …Author: Marija Kuna, Fakhri Mahdi, Alejandro R. Chade, Gene L. Bidwell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964383/
Dec 30, 2010 · 2. The use of cell penetrating peptides for intracellular delivery of ELPs. The ELP drug carrier used for thermal targeting (ELP1) has a molecular weight of 59.1 kDa [], and it enters eukaryotic cells at low levels by an endocytic mechanism.In an attempt to improve the efficiency of cellular internalization of ELP, we modified it at its N-terminus with several CPPs (Figure 1A) [].Author: Gene L. Bidwell, Drazen Raucher
https://chilkotilab.pratt.duke.edu/content/injectable-elp-depots-drug-delivery
We have several projects in the area of injectable drug delivery depots: (1) in a project on the intratumoral delivery of radionuclides, we have covalently conjugated radionuclides to an ELP with a transition temperature below body temperature and injected these conjugates directly into tumors.
https://www.cell.com/cms/10.1016/j.bpj.2013.03.040/attachment/cbd6b885-7bec-4398-af43-f0289027f8aa/mmc1.pdf
Structural and Hydrodynamic Analysis of a Novel Drug Delivery Vector: ELP[V5G3A2-150] Daniel F. Lyons, † Vu Le,§ Gene L. Bidwell III,‡ Wolfgang H. Kramer,¶ Edwin A, Lewis, § Drazen Raucher,† and John J. Correia†* †Department of Biochemistry and ‡Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi; §Department of Chemistry, Mississippi State ...
https://www.sciencedirect.com/science/article/pii/S0006349513003792
May 07, 2013 · Structural and Hydrodynamic Analysis of a Novel Drug Delivery Vector: ... and hydrodynamic properties of a specific ELP being investigated for drug delivery, ELP[V 5 G 3 A 2-150]. ... [V 5 G 3 A 2-150]) is a 758 residue polypeptide with a molecular mass of 59,546.61 Da . It is predicted by the software utility PONDR ...Author: Daniel F. Lyons, Vu Le, Gene L. Bidwell, Wolfgang H. Kramer, Edwin A. Lewis, Drazen Raucher, John J....
https://cancerres.aacrjournals.org/content/67/9/4418
The delivery of anticancer therapeutics to solid tumors remains a critical problem in the treatment of cancer. This study reports a new methodology to target a temperature-responsive macromolecular drug carrier, an elastin-like polypeptide (ELP) to solid tumors. Using a dorsal skin fold window chamber model and intravital laser scanning confocal microscopy, we show that the ELP forms micron ...Author: Matthew R. Dreher, Wenge Liu, Charles R. Michelich, Mark W. Dewhirst, Ashutosh Chilkoti
https://www.sciencedirect.com/science/article/pii/S0168365911005670
Inverse phase transition is the key parameter to realize thermo-targeted drug delivery. It has been demonstrated that the thermal transition temperature (T t) of the ELP-homopolymer is affected by ELP length, concentration, and hydrophobicity . This generation of ELP-based diblock biopolymers is entirely unique with the addition of 15 ...Author: Y Chen, P Youn, DY Furgeson
https://en.wikipedia.org/wiki/Elastin_like_polypeptides
Elastin-like polypeptides (ELPs) are synthesized biopolymers that have become an area of interest for their potentially practical benefits. They may hold key applications in the fields of cancer therapy, tissue scaffolding, and protein purification. For cancer therapy, research has suggested that manipulation of ELPs, through the addition of functional groups, can enable the ELP to conjugate ...
https://www.nature.com/articles/nbt1199_1112
Nov 01, 1999 · We synthesized a gene encoding an ELP with guest residues Val, Ala, and Gly in the ratio 5:2:3 that had a predicted T t of approximately 40°C in water for a molecular mass (M r) greater than 50 ...Author: Dan E. Meyer, Ashutosh Chilkoti
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