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https://link.springer.com/protocol/10.1007%2F978-1-59745-194-9_27
Electroporation is a unique system for drug and gene delivery, as it is possible to very specifically target certain tissues within the body with whatever drug, gene, isotope, or other product is desired in a specific situation. An increasing number of clinical trials are being launched, and sophistication of equipment and protocols continues.Author: Julie Gehl
https://www.researchgate.net/publication/5482761_Electroporation_for_Drug_and_Gene_Delivery_in_the_Clinic_Doctors_Go_Electric
Electroporation is a unique system for drug and gene delivery, as it is possible to very specifically target certain tissues within the body with whatever drug, gene, isotope, or other product is ...Author: Julie Gehl
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/electroporation-advantages-and-drawbacks-for-delivery-of-drug-gene-and-vaccine
In summary, electroporation is one of the physicochemical methods for gene and drug delivery. It is superior in some aspects but also has several drawbacks. Pulse protocol and electrode design need to be optimized to reduce the main side effects e.g., muscle contraction.Author: Azam Bolhassani, Afshin Khavari, Zahra Orafa
https://en.wikipedia.org/wiki/Electroporation
Drug and gene delivery. Electroporation can also be used to help deliver drugs or genes into the cell by applying short and intense electric pulses that transiently permeabilize cell membrane, thus allowing transport of molecules otherwise not transported through a cellular membrane.
https://www.ncbi.nlm.nih.gov/pubmed/12648161
Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Gehl J(1). Author information: (1)Department of Oncology, Herlev Hospital in University of Copenhagen, Herlev, Denmark. Electroporation designates the use of short high-voltage pulses to overcome the barrier of the cell membrane.Author: J. Gehl
https://bme.duke.edu/research/drug-gene-delivery
Important areas in this growing field include development of delivery vehicles such as plasmids, nanoparticles, viruses, liposomes, peptide/protein complexes, and biomaterial scaffolds, as well as studies of drug and gene transport, delivery strategies, delivery barriers, and …
https://www.researchgate.net/publication/10846582_Electroporation_Theory_and_methods_perspectives_for_drug_delivery_gene_therapy_and_research
Request PDF Electroporation: Theory and methods, perspectives for drug delivery, gene therapy and research Electroporation designates the use of short high-voltage pulses to overcome the ...Author: Julie Gehl
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/electroporation
Almost any tissue can be targeted with electroporation, including muscle, skin, heart, liver, lung, and vasculature. This chapter will provide an overview of the theory of electroporation for the delivery of DNA both in individual cells and in tissues and its application for in …
https://www.ncbi.nlm.nih.gov/pubmed/30469344
Nov 21, 2018 · A variety of molecular tools have been developed for cell-based gene therapies, including FDA approved CAR-T immunotherapy, iPSC, cell reprogramming and gene editing. Despite the inspiring results of these applications, intracellular delivery of foreign molecules including nucleic acids and proteins remains challenging.Author: Junfeng Shi, Yifan Ma, Jing Zhu, Yuanxin Chen, Yating Sun, Yicheng Yao, Zhaogang Yang, Jing Xie
https://link.springer.com/chapter/10.1007/978-3-662-53273-7_7
May 05, 2017 · This chapter presents the mechanism of percutaneous penetration enhancement induced by electroporation, discusses factors influencing percutaneous penetration of drug molecules, addresses effects of electroporation on the skin when used in vivo, and describes the potential use of electroporation for transdermal drug delivery.Author: Babu M. Medi, Buddhadev Layek, Jagdish Singh
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