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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
Electroporation Enhanced DNA Vaccine Delivery. Electroporation (EP) is a method to introduce macromolecules such as nucleic acids into cells, either in vivo or in vitro, via the application of brief electric pulses to induce transient and reversible permeabilization of the cell membrane (Figure 1).Author: Niranjan Y Sardesai, David B Weiner
https://bioprocessintl.com/manufacturing/monoclonal-antibodies/electroporation-enhanced-delivery-of-dna-vaccines-320992/
Sep 01, 2011 · And yet for all the promise, early DNA vaccine human clinical trials failed to meet immunogenicity end points. In test after test with early human trials, the one glaring shortcoming of this new vaccine technology was effective delivery of DNA plasmids into cells. Electroporation Enhanced DNA Vaccine Delivery
https://www.sciencedirect.com/science/article/pii/S0952791511000331
Highlights Recent technology advances in DNA vaccines research have led to enhanced immunepotency of this platform. In vivo electroporation (EP) has increased DNA antigen delivery upto a 1000 fold over naked DNA alone. Immune responses and protection from disease challenge with DNA-EP are shown to be comparable or superior to well studied vaccine platforms – viral vectors and live/attenuated ...Author: Niranjan Y Sardesai, David B Weiner
https://www.nature.com/articles/s41598-017-04547-2
Jun 23, 2017 · In vivo electroporation (EP) is used to enhance the uptake of nucleic acids and its association with DNA vaccination greatly stimulates immune responses to …Author: Biliana Todorova, Lucille Adam, Slobodan Culina, Raphaël Boisgard, Frédéric Martinon, Antonio Cosma,...
https://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/electroporation-advantages-and-drawbacks-for-delivery-of-drug-gene-and-vaccine
Electroporation – Advantages and Drawbacks for Delivery of Drug, Gene and Vaccine ... The effect of electroporation on DNA vaccine potency and gene delivery was studied using skin as a target tissue in larger animal species such as pig, macaque and sheep. ... further optimization of DNA vaccine delivery is needed for this vaccine modality to ...Author: Azam Bolhassani, Afshin Khavari, Zahra Orafa
https://cvi.asm.org/content/20/4/491
Apr 01, 2013 · Electroporation delivery of the DNA vaccine led to enhanced antibody responses and to protection against the AI virus challenge. The HI test, cELISA, or indirect ELISA for anti-H5 antibodies might serve as a good predictor of the potency and efficacy of a …Author: Oladele Ogunremi, John Pasick, Gary P. Kobinger, Drew Hannaman, Yohannes Berhane, Alfonso Clavijo, S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816528/
Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-Delivered Genetic Adjuvants. ... Delivery of DNA vaccine with in vivo electroporation enhances cellular immune responses. A DNA vaccine encoding HIV-1 consensus immunogens was injected intramuscularly with or without EP into rhesus macaques.
https://en.wikipedia.org/wiki/Electroporation
Electroporation, or electropermeabilization, is a microbiology technique in which an electrical field is applied to cells in order to increase the permeability of the cell membrane, allowing chemicals, drugs, or DNA to be introduced into the cell (also called electrotransfer). In microbiology, the process of electroporation is often used to transform bacteria, yeast, or plant protoplasts by ...
https://www.creative-biolabs.com/vaccine/dna-delivery-with-electroporation.htm
DNA Delivery with Electroporation. The potential for DNA vaccines in the treatment and prevention of cancer has gained great momentum since initial findings almost 2 decades ago that revealed that genetically engineered DNA can elicit an immune response.
https://www.sciencedirect.com/science/article/abs/pii/S0952791511000331
Highlights Recent technology advances in DNA vaccines research have led to enhanced immunepotency of this platform. In vivo electroporation (EP) has increased DNA antigen delivery upto a 1000 fold over naked DNA alone. Immune responses and protection from disease challenge with DNA-EP are shown to be comparable or superior to well studied vaccine platforms – viral vectors and live/attenuated ...Author: Niranjan Y Sardesai, David B Weiner
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