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https://www.researchgate.net/publication/7448627_Drug_Delivery_to_the_Cochlea_Using_PLGA_Nanoparticles
Drug delivery to the cochlea using PLGA has been investigated in guinea pigs ( Tamura et al., 2005), where deposition in the middle ear allowed delivery of rhodamine to the cochlea within 10 min ...
https://onlinelibrary.wiley.com/doi/abs/10.1097/01.mlg.0000180174.81036.5a
Furthermore, the local application of rhodamine nanoparticles to the RWM was more effective in targeted delivery to the cochlea than systemic application. Conclusions: These findings indicate that PLGA nanoparticles can be an useful drug carrier to the cochlea via local application.Author: Tetsuya Tamura, Tomoko Kita, Takayuki Nakagawa Md, Tsuyoshi Endo, Tae-Soo Kim Md, Tsutomu Ishihara, ...
https://www.ncbi.nlm.nih.gov/pubmed/24568455
Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and biocompatibility with tissue and cells.Author: Fatemeh Sadat Tabatabaei Mirakabad, Kazem Nejati-Koshki, Abolfazl Akbarzadeh, Mohammad Rahmati Yamch...
https://www.ncbi.nlm.nih.gov/pubmed/15719481
PLGA nanoparticles in drug delivery: the state of the art. Bala I(1), Hariharan S, Kumar MN. Author information: (1)Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India. Nanoparticles represent drug delivery systems suitable for most administration routes.Author: Indu Bala, Sarita Hariharan, Mnv Ravi Kumar
https://www.sciencedirect.com/science/article/pii/S0032386115004309
Polymeric nanoparticles (PNPs) are emerging as promising carriers for controlled drug delivery. Poly(D,L-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable and biocompatible polymer in the design nanoparticles for biomedical applications.Herein, we present PNPs prepared from the chemical modification of PLGA with sucrose and a cholic acid moieties (abbreviated as Suc ...Author: Carina I.C. Crucho, Maria Teresa Barros
https://www.researchgate.net/publication/8014818_PLGA_Nanoparticles_in_Drug_Delivery_The_State_of_the_Art
Drug delivery to the cochlea using PLGA has been investigated in guinea pigs ( Tamura et al., 2005), where deposition in the middle ear allowed delivery of rhodamine to the cochlea within 10 min ...
https://www.sciencedirect.com/science/article/pii/S0928098718302392
PLGA nanoparticles modified with the combination of poloxamer 407 and LMWP produced a synergistic enhancement in NP entry to the organ of Corti and stria vascularis (Ramaswamy et al., 2017) Mice/intratympanic injection: Magnetic delivery of methylprednisolone-loaded nanoparticles to the cochlea using an externally applied magnetic fieldAuthor: Jinsong Hao, S. Kevin Li
https://en.wikipedia.org/wiki/Nanoparticles_for_drug_delivery_to_the_brain
Nanoparticles for drug delivery to the brain is a method for transporting drug molecules across the blood–brain barrier (BBB) using nanoparticles.These drugs cross the BBB and deliver pharmaceuticals to the brain for therapeutic treatment of neurological disorders.
https://link.springer.com/article/10.1007%2Fs11051-012-1316-4
Nov 25, 2012 · Despite fine qualities, using PLGA polymeric nanoparticles for in vivo applications still remains an open challenge due to many factors such as poor stability in water, big diameter (150–200 nm), and the removal of these nanocarriers from the blood stream by the liver and spleen thus reducing the concentration of drugs drastically in tumor ...Author: Erica Locatelli, Mauro Comes Franchini
http://www.nanovexbiotech.com/858-2/
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles for drug delivery . Poly(lactic-co-glycolic acid) (PLGA) is one of the most commonly used biodegradable synthetic polymer to generate biocompatible nanoparticles since it is a US FDA* and EMA**-approved platform to the delivery of drugs in humans.
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