Gene Therapy Gene Delivery Systems

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Delivery systems for gene therapy - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722627/
    Although gene therapy as a treatment for disease holds great promise, progress in developing effective clinical protocols has been slow. The problem lies in the development of safe and efficient gene-delivery systems. This review will evaluate the problems and the potential solutions in this new field of medicine.

Gene therapy and DNA delivery systems - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0378517313010351
    Gene therapy is a promising new technique for treating many serious incurable diseases, such as cancer and genetic disorders. The main problem limiting the application of this strategy in vivo is the difficulty of transporting large, fragile and negatively charged molecules like DNA into the nucleus of the cell without degradation. The key to success of gene therapy is to create safe and ...Author: D. Ibraheem, A. Elaissari, H. Fessi

Non-Viral Delivery Systems in Gene Therapy IntechOpen

    https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
    In this chapter we explain the concept and aim of gene therapy, the different gene delivery systems and therapeutic strategies, how genes are delivered and how they reach the target. 2. Aim and concept of gene therapy with non-viral vectorsAuthor: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís

Gene Delivery Systems: Recent Progress in Viral and Non ...

    https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
    Current gene delivery systems are divided into three categories: viral-based, non-viral based, and combined hybrid systems. Viral gene delivery systems consist of viruses that are modified to be replication-deficient which can deliver genes to the target cells to provide expression.Author: Erdal Cevher, Ali Demir Sezer, Emre Şefik Çağlar

Viral and nonviral delivery systems for gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
    Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).

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