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https://www.ondrugdelivery.com/scaling-high-dose-delivery-lungs/
João Ventura Fernandes, Gonçalo Rebelo de Andrade and Peter Villax describe the scaling up of the currently marketed TwinCaps® inhaler into the new TwinMax™ design for high-dose delivery of challenging drug-alone formulations in single to short-term treatments and emergency situations.
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
A particular advantage is the possibility for local drug delivery in the lung. The extension of using similar nanoformulation platforms for delivery of antimicrobial peptides holds promise for the future and is currently under development in FORMAMP.
http://action.lung.org/site/DocServer/MDIDrugDeliveryLancetMar2011.pdf?docID=8161
Measuring aerosol drug delivery The inhaled route can deliver a suffi cient amount of the drug to airway surfaces throughout the lung to give rise to a clinical response, although dose delivery is dependent on the adequate use of an appropriate administered drug dose and eff ective inhaler use. In …
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.2010.01234.x
Objective There is a growing interest in developing bioresponsive drug delivery systems to achieve greater control over drug release than can be achieved with the conventional diffusion controlled polymeric delivery systems. While a number of such systems have been studied for oral or parenteral delivery, little or no work has been done on bioresponsive delivery systems for inhalation.Author: Neeraj Sivadas, Sally-Ann Cryan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · 2. A few observations on anticancer treatment. A typical in vitro study of targeted anticancer drug delivery is based on cultured human cancer cells which express a unique surface marker specifically selected to test the targeted delivery strategy being examined. Cytotoxicity is commonly examined by the addition of a drug delivery system directly to cells grown as a monolayer …
https://www.researchgate.net/publication/230733979_The_lungs_and_drug_delivery
Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for local and systemic treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417302/
Sep 04, 2011 · Introduction. D rug delivery by aerosol inhalation is a well-established procedure in the treatment of pulmonary diseases as it has potential advantages over oral and intravenous routes of delivery. The use of inhaled aerosols allows selective treatment of the lungs directly by achieving high drug concentrations in the airway.
https://journal.pda.org/content/65/5/513
Sep 01, 2011 · Pulmonary drug delivery is a developing technology in which medication is inhaled through the lungs and enters the bloodstream through the alveolar epithelium. Pulmonary drug delivery provides a noninvasive, alternative method to subcutaneous injection, and also intravenous injection. The delivery device plays a major role in the efficiency of pulmonary delivery, and great strides have been ...Author: Basavaraj K. Nanjwade, Sagar A. Adichwal, Kishori R. Gaikwad, Kemy A. Parikh, F. V. Manvi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424884/
Therefore, their use is rapidly expanding, especially for drug delivery to the lungs. Chitosan, one of the most famous and commonly used micelle, was recently used as nanoparticle to deliver drug to the lungs, especially for drugs with high first pass phenomena such as isoniazid.
http://news.rice.edu/2017/02/28/inhaler-study-how-much-medicine-makes-it-to-lungs/
Feb 28, 2017 · In the worst case, if someone does everything wrong, that drops to 7 percent. We know the two extremes, but the vast majority of everyday use falls somewhere in the middle. In this study, we have been able to objectively measure the errors, and, using new technology, learn about their impact on drug delivery to the lungs.”
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