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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826320/
Oct 28, 2013 · Phagocytosis occurs after the multivalent drug delivery system comes in contact with the macrophage where they spread the cell membrane around the particles to engulf them. Macrophages recognize the delivery systems via the recognition of opsonins present over them or through interaction with scavenger receptors present on Kupffer cells.Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
https://www.sciencedirect.com/topics/medicine-and-dentistry/hepatic-clearance
Hepatic clearance is the net result of drug uptake into the hepatocyte, followed by metabolism and biliary excretion, with possible efflux of drug back into the circulation from the liver cell. From: Pharmacology, 2009
https://www.hindawi.com/journals/bmri/2013/382184/
Normally most of the drugs achieve high hepatic concentration, still their targeting is necessary because liver is the major organ in the body equipped for uptake, detoxification, metabolic transformation, and excretion of xenobiotics into bile by means of carrier-mediated mechanism.Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
https://derangedphysiology.com/main/cicm-primary-exam/required-reading/pharmacokinetics/Chapter%203336/hepatic-clearance
Intrinsic clearance is the intrinsic ability of the liver to remove (metabolise) the drug in absence of restrictions imposed on drug delivery to the liver cell by blood flow or protein binding. The effect of liver blood flow on hepatic clearance depends on the hepatic extraction ratio of the drug.
https://www.ncbi.nlm.nih.gov/pubmed/30886124
Activation of hepatic stellate cells (HSCs) is the key step during liver fibrogenesis, and its mechanism has been extensively studied by various cell culture and animal models. Targeted delivery of therapeutic agents to activated HSCs is therefore critical for the successful treatment of liver fibrosis.Author: Zhijin Chen, Akshay Jain, Hao Liu, Zhen Zhao, Kun Cheng
http://tmedweb.tulane.edu/pharmwiki/doku.php/hepatic_drug_clearance
Hepatic drug clearance can be defined as the volume of blood perfusing the liver that is cleared of the drug per unit of time. There are three major parameters that determine drug elimination by the liver: blood flow through the liver (Q), which reflects drug delivery to the liver
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