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https://www.sciencedirect.com/topics/neuroscience/hepatic-portal-system
The main vessel of the hepatic portal system is the hepatic portal vein (Figures 3.31 and 3.32), a large vein that lies in the gastrohepatoduodenal ligament alongside the hepatic artery and anterior part of the bile duct.The hepatic portal vein is formed by the confluence of three main vessels, the gastric, pancreaticomesenteric, and lienomesenteric veins.
https://www.sciencedirect.com/topics/medicine-and-dentistry/hepatic-clearance
Jitender Madan, in Drug Targeting and Stimuli Sensitive Drug Delivery Systems, 2018 Hepatic clearance is a saturated process. After oral dosing, the drug reaches the liver by travelling through portal vein. The concentration of drug that reaches the liver determines the amount metabolized.
http://www.authorstream.com/Presentation/chetanmatholiya-1800264-small-intestine-drug-delivery-system/
May 05, 2013 · Perfusion of the Gastrointestinal Tract: The blood flow to the GI tract is important in carrying absorbed drug to the systemic circulation Once the drug is absorbed from the small intestine, it enters via the vessels to the hepatic- portal vein and the liver prior to reaching the systemic circulation Any decrease in mesenteric blood flow, as in ...
https://www.hindawi.com/journals/bmri/2013/382184/
These exciting evidences suggested that Lf-R might be a promising candidate for hepatocellular carcinoma targeting due to its high affinity for ASGP-R, and developing a hepatic carcinoma targeting drug delivery system employing the ASGP-R targeting …Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787047/
Hepatic-directed vesicle insulin (HDV-I), a novel investigational vesicle (<150 nm diameter) insulin delivery system that carries insulin and a specific hepatocyte-targeting molecule (HTM) in its phospholipid bilayer and has the ability to mimic a portal vein insulin infusion remotely [subcutaneous (SC) HDV-I] and noninvasively (oral HDV-I), has been developed.Author: W. Blair Geho, Hans C. Geho, John R. Lau, Theophilus J. Gana
http://downloads.hindawi.com/journals/bmri/2013/382184.pdf
Review Article Efficient Hepatic Delivery of Drugs: Novel Strategies ... ity of the drug delivery system selected for the release of free ... contribute to hepatic uptake of particulate material. ere-fore, the drugs that enter the liver as such or in the form of
http://globalresearchonline.net/journalcontents/v21-1/13.pdf
hepatic first-pass effect. The rectum offers a relatively constant environment for drug delivery provided the drug is presented in a well absorbable form. The rate controlled dosage forms resulting in constant steady-state concentration of drugs in plasma selected therapeutic indications.
http://www.authorstream.com/Presentation/munugoti.suman86-1134578-liver-targetting/
Aug 04, 2011 · Slide 2: Concept Introduction Hepatic Inflammation and Fibrosis Liver Cirrhosis Drug Targeting to the Liver Anti-inflammatory Drugs Anti-fibrotic Drugs Targeting of Anti-inflammatory Drugs for the Treatment of Liver Fibrosis Selective Drug Delivery for the Treatment of Other Hepatic Disorders Conclusion References CONTENTS 2
http://ijpsr.com/bft-article/liver-specific-drug-targeting-strategies-a-review/?view=fulltext
Liver targeting: The liver is a critical target tissue for drug delivery because many fatal conditions including chronic hepatitis, enzyme deficiency, and hepatoma occur in hepatocytes.
https://en.wikipedia.org/wiki/First_pass_effect
After a drug is swallowed, it is absorbed by the digestive system and enters the hepatic portal system. It is carried through the portal vein into the liver before it reaches the rest of the body.
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