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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse. J Pharmacol Exp Ther. 2010; 333:961–969. [Google Scholar] Boado RJ, Pardridge WM. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey.Author: William M Pardridge
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases. Focused ultrasound (FUS) has been developed as a non-invasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain.Author: Alison Burgess, Kullervo H. Hynynen
https://www.hindawi.com/journals/bmri/2014/869269/
However, tumor necrosis factor receptor-IgG fusion protein is prepared for targeted drug delivery across the human blood brain barrier. The tumor necrosis factor-alpha receptor (TNFR) contains an extracellular domain (ECD) that can be used in neurotherapeutics of stroke, brain injury, or chronic neurodegeneration [101, 110]. As nascent TNFR ECD ...Author: Ravi Kant Upadhyay
https://www.mayo.edu/research/documents/heterogeneity-in-drug-delivery-across-blood-brain-barrier/doc-20475200
Heterogeneity in Drug Delivery across the Blood-Brain Barrier Impacts Efficacy of Depatuxizumab Mafodotin (ABT-414) Therapy in Glioblastoma Bianca-Maria Marin1, Ann C. Mladek1, Danielle M. Burgenske1, Gaelle Muller-Greven2, Mark A Schroeder1, Lihong He1, Zeng Hu1, Katrina A. Bakken1, Brett L Carlson1, Paul Decker3, Candece Gladson2, William F. Elmquist4, Jann N. Sarkaria1
https://www.onlinelibrary.wiley.com/doi/full/10.1002/smll.201701921
Drug Delivery to the Brain across the Blood–Brain Barrier Using Nanomaterials. Correction(s) for this article ... and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the ...Author: Yung-Hao Tsou, Xue-Qing Zhang, He Zhu, Sahla Syed, Xiaoyang Xu
https://pubs.acs.org/doi/pdf/10.1021/mp400170b
Drug Delivery across the Blood−Brain Barrier T he delivery of drugs to the central nervous system (CNS) remains a challenge in the treatment of neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and stroke. The major challenge to CNS drug delivery is the presence of the blood−brain barrier (BBB), which limits the
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