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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse. J Pharmacol Exp Ther. 2010; 333:961–969. [Google Scholar] Boado RJ, Pardridge WM. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey.Author: William M Pardridge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases. Focused ultrasound (FUS) has been developed as a non-invasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain.Author: Alison Burgess, Kullervo H. Hynynen
https://www.ncbi.nlm.nih.gov/pubmed/31916480
Jan 09, 2020 · The blood-brain barrier (BBB) has a significant contribution to homeostasis and protection of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the treatment of CNS disorders. To overcome this limitation, the use of nanocarriers for drug delivery across the BBB has recently been exploited.
https://www.mayo.edu/research/documents/heterogeneity-in-drug-delivery-across-blood-brain-barrier/doc-20475200
Heterogeneity in Drug Delivery across the Blood-Brain Barrier Impacts Efficacy of Depatuxizumab Mafodotin (ABT-414) Therapy in Glioblastoma Bianca-Maria Marin1, Ann C. Mladek1, Danielle M. Burgenske1, Gaelle Muller-Greven2, Mark A Schroeder1, Lihong He1, Zeng Hu1, Katrina A. Bakken1, Brett L Carlson1, Paul Decker3, Candece Gladson2, William F. Elmquist4, Jann N. Sarkaria1
https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2012.126
Drug transport across the blood–brain barrier William M Pardridge The blood–brain barrier (BBB) prevents the brain uptake of most pharmaceuticals. This property arises from the epithelial-like tight junctions within the brain capillary endothelium. The BBB is anatomically and functionally distinct from the blood–cerebrospinal
https://www.hindawi.com/journals/bmri/2014/869269/
However, tumor necrosis factor receptor-IgG fusion protein is prepared for targeted drug delivery across the human blood brain barrier. The tumor necrosis factor-alpha receptor (TNFR) contains an extracellular domain (ECD) that can be used in neurotherapeutics of stroke, brain injury, or chronic neurodegeneration [101, 110]. As nascent TNFR ECD ...Author: Ravi Kant Upadhyay
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