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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
Upon injection, DNA was rapidly degraded by enzymes and eliminated from plasma due to extensive uptake by the liver (Kawabata et al., 1995). Chemical modification and a proper delivery method can reduce uptake by RES and protect nucleic acids from degradation by ubiquitous nucleases, which increase stability and efficacy of gene therapy.Author: Yi Zhao, Leaf Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915782/
Regardless of which steps in the delivery or gene expression pathway are the major bottlenecks, the specificity with which hepatoma cells are transfected is promising for further mechanistic study or for in vivo experiments. The high specificity for delivery to liver cancer while avoiding healthy liver cells in co-culture is intriguing.Author: Stephany Y. Tzeng, Luke J. Higgins, Martin G. Pomper, Jordan J. Green
https://altogen.com/product/liver-in-vivo-transfection-kit/
Liver-targeted In Vivo Transfection Reagent. Biodegradable lipid liposome-based reagent; Liposome conjugated complexes are stable in serum (16h) Efficient delivery to the liver tissue (via systemic administration) and liver tumors (via intratumoral administration) Efficient siRNA, shRNA, microRNA, and plasmid DNA delivery; Minimal toxicity
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201909691
Oct 24, 2019 · Here, we show how six‐letter GACTZP DNA contributes this property in two parts of a nanoassembly: 1) in an aptamer evolved from a six‐letter DNA library to selectively bind liver cancer cells; and 2) in a six‐letter self‐assembling GACTZP nanotrain that carries the drug doxorubicin.Author: Liqin Zhang, Sai Wang, Zunyi Yang, Shuichi Hoshika, Sitao Xie, Jin Li, Xigao Chen, Shuo Wan, Long Li...
https://www.sciencedirect.com/science/article/pii/S0378517313010351
Hydrodynamic gene delivery is an easier approach used to insert DNA effectively into the internal organs, especially the liver (Zhang et al., 1999). It was first used in 1996 by Budker and his team who succeeded in inserting plasmid DNA into the skeletal muscle of rats by …Author: D. Ibraheem, A. Elaissari, H. Fessi
https://pubs.acs.org/doi/10.1021/nn4012384
Structural behaviour and gene delivery in complexes formed between DNA and arginine-containing peptide amphiphiles. Soft Matter 2016, 12 (45) , 9158-9169. DOI: 10.1039/C6SM01618A. Samuel T. Crowley, Kevin G. Rice. “Evolving nanoparticle gene delivery vectors for the liver: What has been learned in …Author: Yunxia Hu, Matthew T. Haynes, Yuhua Wang, Feng Liu, Leaf Huang
https://www.sciencedirect.com/science/article/pii/S014296121300149X
Gene therapy is a very promising technology for treatment of liver diseases. Minicircle DNA (MCDNA) is a versatile gene vector, which possesses excellent features in bio-safety and duration of transgene expression. However, its application has been hampered by the lack of an efficient gene delivery system.Author: Lin Gao, Lisi Xie, Xiaojing Long, Zhiyong Wang, Cheng Yi He, Zhi Ying Chen, Lei Zhang, Xiang Nan, Hu...
https://www.nature.com/articles/nbt0100_33
Jan 01, 2000 · Over the past 30 years, DNA delivery, especially via the nonviral route (i.e., transfection), has become a powerful and popular research tool for elucidating gene structure, regulation, and function.Author: Dan Luo, W. M. Saltzman
https://www.researchgate.net/publication/51713621_DNA_delivery_to_'ex_vivo'_human_liver_segments
Hydrodynamic injection is an efficient procedure for liver gene therapy in rodents but with limited efficacy in large animals, using an 'in vivo' adapted regional hydrodynamic gene delivery system.
https://ir.uiowa.edu/etd/1577/
Nonviral gene delivery vectors face many chges in vivo. The vectors must protect DNA from nucleases while it moves through the bloodstream, they must avoid nonspecific uptake, they must be enter the correct cells, and must enter the nucleus before the DNA can be expressed.Author: Samuel Thomas Crowley
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