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https://www.nature.com/articles/s41598-018-21539-y
Feb 20, 2018 · By our simple centrifugation method, we found that the isolated mitochondria could be successfully transferred into target cells, including mitochondrial DNA-deleted Rho0 cells and dexamethasone ...Author: Mi Jin Kim, Jung Wook Hwang, Chang-Koo Yun, Youngjun Lee, Yong-Soo Choi
https://www.researchgate.net/publication/51485131_DNA_Delivery_to_Mitochondria_Sequence_Specificity_and_Energy_Enhancement
Mitochondria are competent for DNA uptake in vitro, a mechanism which may support delivery of therapeutic DNA to complement organelle DNA mutations.
https://www.sciencedirect.com/science/article/pii/S0168365903002979
DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. ... the efficiency of DNA delivery to mitochondria in living cells can currently only be assessed based on the direct detection of the internalized DNA. Since the release of the DNA from the carrier system (DQAsomes) upon contact with mitochondria is a crucial element ...Author: Gerard G.M D’Souza, Ram Rammohan, Shing-Ming Cheng, Vladimir P Torchilin, Volkmar Weissig
https://link.springer.com/article/10.1007%2Fs11095-011-0516-4
Jul 12, 2011 · Purpose. Mitochondria are competent for DNA uptake in vitro, a mechanism which may support delivery of therapeutic DNA to complement organelle DNA mutations.We document here key aspects of the DNA import process, so as to further lay the ground for …Author: Noha Ibrahim, Noha Ibrahim, Hirokazu Handa, Anne Cosset, Milana Koulintchenko, Milana Koulintchenko,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225103/
Barriers against delivery of exogenous DNA into mitochondrial matrix. There are three main barriers (words in blue) that need to be overcome to deliver DNA into mitochondria: the cell membrane (against cell internalization, (1), the endosomes (against endosome escape, (2), and mitochondrial double membranes (against mitochondrial import, (3).Author: Yoon-ha Jang, Kwang-il Lim
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/49/issue/1
Drug and DNA Delivery to Mitochondria. V. Weissig and V.P. Torchilin. Volume 49, Issues 1–2, Pages 1-216 (2 July 2001) Download full issue. Previous vol/issue. ... Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems. Volkmar Weissig, Vladimir P Torchilin. Pages 127-149 Download PDF.
https://www.targetmol.com/compound-library/Mitochondrial-Targeting-Compound-Library
Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer). A number of pre-clinical and clinical data have shown that ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356643/
May 15, 2012 · Although there are several reports describing DNA import into mitochondria by means of nucleic acid-protein conjugation, electroporation, or bacterial conjugation, there remain significant obstacles to correcting any mtDNA mutation in living animals: There is no delivery system for DNA into mitochondria, and there are no selectable markers for ...Author: Hong Yu, Rajeshwari D. Koilkonda, Tsung Han Chou, Vittorio Porciatti, Sacide S. Ozdemir, Vince Chiod...
https://www.nature.com/articles/s41598-017-10870-5
Sep 06, 2017 · Mitochondria are organelles responsible for a large part of the cellular ATP production. These dynamic organelles have their own DNA, and are …Author: Jui-Chih Chang, Fredrik Hoel, Ko-Hung Liu, Yau-Huei Wei, Yau-Huei Wei, Fu-Chou Cheng, Shou-Jen Kuo, ...
https://pubs.acs.org/doi/10.1021/jacs.0c00188
Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although the most effective way to deliver drugs to mitochondria is by covalently linking them to a lipophilic cation, the in vivo delivery of free drugs still constitutes a critical bottleneck. Herein, we report the design of a mitochondria-targeted metal–organic framework ...Author: Salame Haddad, Isabel Abanades Lazaro, Marcus Fantham, Ajay Mishra, Joaquin Silvestre-Albero, Johann...
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