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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147627/
Jan 31, 2005 · Cationic polymers used for nucleic acid delivery acquire their charge from primary, secondary, tertiary, and/or quaternary amino groups, which are capable of forming electrostatic complexes with DNA under physiologic conditions.Author: H. Eliyahu, Y. Barenholz, A. J. Domb
https://www.mdpi.com/1420-3049/10/1/34
Nucleic acid delivery has many applications in basic science, biotechnology, agriculture, and medicine. One of the main applications is DNA or RNA delivery for gene therapy purposes. Gene therapy, an approach for treatment or prevention of diseases associated with defective gene expression, involves the insertion of a therapeutic gene into cells, followed by expression and production of the required proteins.Author: H. Eliyahu, Y. Barenholz, A. J. Domb
https://www.mdpi.com/1420-3049/10/1/34/htm
Cationic polymers used for nucleic acid delivery acquire their charge from primary, secondary, tertiary, and/or quaternary amino groups, which are capable of forming electrostatic complexes with DNA under physiologic conditions.Author: H. Eliyahu, Y. Barenholz, A. J. Domb
https://www.ncbi.nlm.nih.gov/pubmed/18007276
Jan 31, 2005 · Nucleic acid delivery has many applications in basic science, biotechnology, agriculture, and medicine. One of the main applications is DNA or RNA delivery for gene therapy purposes. Gene therapy, an approach for treatment or prevention of diseases associated with defective gene expression, involves the insertion of a therapeutic gene into cells, followed by expression and production of the …Author: H. Eliyahu, Y. Barenholz, A. J. Domb
https://www.researchgate.net/publication/5840328_Polymers_for_DNA_delivery
delivery entails direct injection of DNA (naked DNA) into the target organ. This method was use ful in delivery of DNA into skeletal muscle [11–12], liver [13], heart muscle [14], and tumors [15].
https://www.mdpi.com/1420-3049/24/20/3744/htm
Cationic polymers, such as polyethyleneimine are capable of condensing DNA to nanoparticles and facilitate gene delivery. Lack of biodegradation of polymeric gene delivery vehicles poses significant toxicity because of the accumulation of polymers in the tissue.Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai
https://www.sciencedirect.com/science/article/pii/S0168365999000759
Copolymers of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and N-isopropylacryl amide (NIPAAm) of various monomer ratios and molecular weights were evaluated as carrier systems for DNA delivery. All copolymers, even with a low DMAEMA content of 15 mol%, were able to bind to DNA at 25°C.Author: W.L.J Hinrichs, N.M.E Schuurmans-Nieuwenbroek, P van de Wetering, W.E Hennink
https://www.sciencedirect.com/science/article/pii/S0168365907006220
Poly(l-lysine) (pLL) is one of the polymers that have been thoroughly investigated as a non-viral gene delivery vector [50]. However, complexes of this polymer and DNA have relatively low transfection activity and a rather high toxicity, especially when high molecular weight pLL (Mw 25 kDa) is used.Author: Jordy Luten, Cornelus F. van Nostrum, Stefaan C. De Smedt, Wim E. Hennink
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Gene delivery methods include recombinant viruses and synthetic materials such as lipids, polypeptides and polymers. Safety concerns limit the use of viral vectors. Non-viral gene delivery is typically much safer but suffers from generally unsatisfactory delivery efficiency.Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
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