Dna Delivery Into Mitochondria

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Delivery of exogenous mitochondria via centrifugation ...

    https://www.nature.com/articles/s41598-018-21539-y
    Feb 20, 2018 · We observed changes in mitochondrial-related functions after delivery of various quantities of mitochondria into normal cells or cells in which mitochondrial dysfunction had been induced.Author: Mi Jin Kim, Jung Wook Hwang, Chang-Koo Yun, Youngjun Lee, Yong-Soo Choi

(PDF) DNA Delivery to Mitochondria: Sequence Specificity ...

    https://www.researchgate.net/publication/51485131_DNA_Delivery_to_Mitochondria_Sequence_Specificity_and_Energy_Enhancement
    DNA Delivery to Mitochondria: Sequence Specificity and Energy Enhancement ... to optimize DNA delivery into mitochondria and open the prospect of targeting whole mitochondrial genomes or complex ...

Recent Advances in Mitochondria-Targeted Gene Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225103/
    Barriers against delivery of exogenous DNA into mitochondrial matrix. There are three main barriers (words in blue) that need to be overcome to deliver DNA into mitochondria: the cell membrane (against cell internalization, (1), the endosomes (against endosome escape, (2), and mitochondrial double membranes (against mitochondrial import, (3).Author: Yoon-ha Jang, Kwang-il Lim

DQAsome-mediated delivery of plasmid DNA toward ...

    https://www.sciencedirect.com/science/article/pii/S0168365903002979
    Our strategy for the delivery of DNA into the matrix of mitochondria is based upon the DQAsomal transport of a DNA-signal peptide conjugate to mitochondria, the selective liberation of this conjugate from DQAsomes at the mitochondrial membrane followed by DNA uptake via the mitochondrial protein import machinery.Author: Gerard G.M D’Souza, Ram Rammohan, Shing-Ming Cheng, Vladimir P Torchilin, Volkmar Weissig

RNA delivery into mitochondria - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S0169409X01001351
    Jul 02, 2001 · A possibility of use imported (t)RNAs as vectors for foreign RNA delivery into the mitochondria was demonstrated for plants (several additional nucleotides in the anticodon loop, ), for Tetrahymena (additional nucleotides in the D-loop, , ), for mammalians (additional nucleotides in 5S rRNA ) and for trypanosomatids (synthetic non-spliced ...Author: N.S Entelis, N.S Entelis, O.A Kolesnikova, O.A Kolesnikova, R.P Martin, I.A Tarassov

(PDF) Import of Proteins and Nucleic Acids into Mitochondria

    https://www.researchgate.net/publication/325617340_Import_of_Proteins_and_Nucleic_Acids_into_Mitochondria
    Considering continued efforts towards developing systems to import DNA into mitochondria [87, 88], and the presence of potentially unidentified DNA repair mechanisms [26,27,85,[89][90][91][92 ...

Mitochondrial leader sequence--plasmid DNA conjugates ...

    https://www.ncbi.nlm.nih.gov/pubmed/16154389
    We present data to demonstrate that oligonucleotides as well as plasmid DNA conjugated to a mitochondrial leader sequence (MLS) co-localize with mitochondria when delivered into mammalian cells by DQAsomes. In contrast to a commercially available DNA delivery vector, our vesicles appear to have a pronounced specificity for mitochondria.Author: Gerard G.M. D'Souza, Sarathi V. Boddapati, Volkmar Weissig

DNA Delivery to Mitochondria: Sequence Specificity and ...

    https://link.springer.com/article/10.1007%2Fs11095-011-0516-4
    Jul 12, 2011 · ATP hydrolysis has to occur during the DNA uptake process and might trigger phosphorylation of co-factors. Our data contribute critical information to optimize DNA delivery into mitochondria and open the prospect of targeting whole mitochondrial genomes or complex constructs into mammalian organelles in vitro and in vivo.Author: Noha Ibrahim, Noha Ibrahim, Hirokazu Handa, Anne Cosset, Milana Koulintchenko, Milana Koulintchenko,...

Introduction of Plasmid DNA into Isolated Mitochondria by ...

    http://www.jbc.org/content/272/8/5342.full
    Feb 21, 1997 · Although successful in plant cells and yeast, biolistic delivery has so far not been applicable to mammalian mitochondria. Early attempts to introduce DNA into “mega”-mitochondria of liver cells by systemic delivery in encapsulating liposomes have not beenAuthor: Jean-Marc Collombet, Vanessa C. Wheeler, Frank Vogel, Charles Coutelle

mtDNA and Mitochondrial Diseases Learn Science at Scitable

    https://www.nature.com/scitable/topicpage/mtdna-and-mitochondrial-diseases-903/
    The mitochondrial genome is not enveloped, and is it not packaged into chromatin.; The mitochondrial genome contains few, if any, noncoding DNA sequences.

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