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https://www.hindawi.com/journals/jdd/2011/326497/
Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be ...Author: Daniel A. Balazs, Wt. Godbey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066571/
Dec 15, 2010 · The liposome thus formed is a result of energetic contributions by Van der Waals forces and electrostatic binding to the DNA which partially dictates liposome shapes . Because of the polyanionic nature of DNA, cationic (and neutral) lipids are typically used for gene delivery, while the use of anionic liposomes has been fairly restricted to the ...Author: Daniel A. Balazs, Wt. Godbey
https://pubs.acs.org/doi/abs/10.1021/la400859e
Jun 27, 2013 · The success of common nonviral gene delivery vehicles, lipoplexes and polyplexes, is limited by the toxicity and instability of these charged molecules. Stealth liposomes could provide a stable, safe alternative to cationic DNA complexes for effective gene delivery. DNA encapsulations in three stealth liposomal formulations prepared by thin film, reverse phase evaporation, and asymmetric ...Author: Rachel M. Levine, Timothy R. Pearce, Maroof Adil, Efrosini Kokkoli
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066342/
Dec 31, 2010 · CS-PLL540 and CS-PLL540DC exhibited higher efficiency of DNA delivery throughout the small intestine. The expressed protein signals were found to be similar in the duodenum, jejunum, and ileum. Meanwhile, the GFP expression from naked DNA, plain liposome, and CS-PLL541 and CS-PLL541DC was poor (data not shown).Author: Sunee Channarong, Wanpen Chaicumpa, Nuttanan Sinchaipanid, Ampol Mitrevej
https://www.sciencedirect.com/science/article/pii/S0928493117304575
Jun 01, 2017 · Radwan Almofti et al. revealed that DNA-induced liposome-liposome fusion is responsible for the change in liposome size upon incorporation of DNA . The positive charge of liposomes led by amine groups of cationic lipid, DOTAP, was reduced but remained positive via incorporation of DNA, which supports the formation of liposome-DNA complexes.Author: M. Rasoulianboroujeni, G. Kupgan, F. Moghadam, M. Tahriri, A. Boughdachi, P. Khoshkenar, J.J. Ambros...
http://arbutusbio.com/docs/Liposome_Formulations_Proof_for_Distribution.pdf
Liposomal Formulations for Nucleic Acid Delivery Ian MacLachlan ... LIPOSOMAL FORMULATIONS FOR NUCLEIC ACID DELIVERY 239 ... [23–26]. Fusogenic liposomes facilitate the intracellular delivery of complexed plasmid DNA by fusing with the membranes of the target cell. Fusion may occur at a …
https://www.sciencedirect.com/science/article/pii/S0378517313010351
Gene therapy is a promising new technique for treating many serious incurable diseases, such as cancer and genetic disorders. The main problem limiting the application of this strategy in vivo is the difficulty of transporting large, fragile and negatively charged molecules like DNA into the nucleus of the cell without degradation. The key to success of gene therapy is to create safe and ...Author: D. Ibraheem, A. Elaissari, H. Fessi
https://www.nature.com/articles/nbt0797-647
Jul 01, 1997 · To increase cationic liposome-mediated intravenous DNA delivery extruded DOTAPicholesterol lipo-somes were used to form complexes with DNA, resulting in enhanced expression of the chloramphenicol ...Author: Nancy Smyth Templeton, Danilo D. Lasic, Peter M. Frederik, Helmut H. Strey, David D. Roberts, George...
https://www.cd-bioparticles.net/liposomes-for-dna-rna-delivery
DC-Cholesterol Liposomes for DNA/RNA Delivery. DC-Cholesterol is a cationic analogue of cholesterol. DC cholesterol by itself doesn't form liposomes and it should be added to a matrix lipid
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