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https://www.sciencedirect.com/science/article/pii/S1773224711500504
DNA and RNA delivery to the lungs using polymers O. Argyros, 1 M.J. Serginson, 2 A.D. Miller, 1 J.H.G. Steinke, 2 M. Thanou, 1 ⠎ [email protected] 1 King’s College London, Institute of Pharmaceutical Sciences, 150 Stamford Street, London SE1 9NH, United Kingdom King’s College London, Institute of Pharmaceutical Sciences 150 Stamford Street London SE1 9NH United Kingdom 2 ...Author: O. Argyros, M. J. Serginson, Ann Miller, J. H G Steinke, Maya Thanou
https://www.researchgate.net/publication/280266172_DNA_and_RNA_delivery_to_the_lungs_using_polymers
DNA and RNA delivery to the lungs using polymers Article in Journal of Drug Delivery Science and Technology 21(4):323-330 · December 2011 with 13 Reads How we measure 'reads'
https://www.researchgate.net/publication/308813152_Polymer-Lipid_Nanoparticles_for_Systemic_Delivery_of_mRNA_to_the_Lungs
Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs ... of different kinds of nucleic acids like plasmid DNA, messenger RNA, and short-interfering RNA into various mammalian ...
https://phys.org/news/2018-07-materials-delivery-therapeutic-messenger-rna.html
Jul 16, 2018 · Unlike DNA, mRNA is not permanently inserted into a cell's genome, so it could be used to produce a therapeutic protein that is only needed temporarily. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147627/
Jan 31, 2005 · Nucleic acid delivery has many applications in basic science, biotechnology, agriculture, and medicine. One of the main applications is DNA or RNA delivery for gene therapy purposes. Gene therapy, an approach for treatment or prevention of diseases associated ...Author: H. Eliyahu, Y. Barenholz, A. J. Domb
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891846/
Dec 28, 2013 · Successful delivery of DNA and RNA have been achieved and some ongoing clinical trials showed great potential . Using a miR-155 Cre-loxP tetracycline-controlled knockin mouse model, pre-B-cell tumors were dependent on high miR-155 expression where withdrawal of miR-155 using doxycycline caused rapid tumor regression. Systemic delivery of anti ...Author: Yu Zhang, Zaijie Wang, Richard A. Gemeinhart
https://link.springer.com/article/10.1007/s12195-018-0536-9
Jun 19, 2018 · However, efficient delivery of mRNA is still one of the key challenges for its broad applications in the clinic. Recently, lipid polymer hybrid nanoparticles (LPNs) are evolving as a promising class of biomaterials for RNA delivery, which integrate the …Author: Weiyu Zhao, Chengxiang Zhang, Bin Li, Xinfu Zhang, Xiao Luo, Chunxi Zeng, Wenqing Li, Min Gao, Yizho...
https://www.nanowerk.com/nanotechnology-news2/newsid=50678.php
Jul 16, 2018 · These polymers are biodegradable, and unlike many other delivery polymers, they do not have a strong positive charge, which may make them less likely to damage cells. MIT researchers have designed nanoparticles that can deliver messenger RNA to specific organs, in this case, the liver. Cells expressing the synthetic mRNA show up as red.
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo —however, this section will focus mainly on the development of non-viral materials (Table 1). Of the non-viral RNA delivery vehicles, nanoparticles are perhaps the most studied.Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.mdpi.com/1420-3049/10/1/34/htm
Nucleic acid delivery has many applications in basic science, biotechnology, agriculture, and medicine. One of the main applications is DNA or RNA delivery for gene therapy purposes. Gene therapy, an approach for treatment or prevention of diseases associated with defective gene expression, involves the insertion of a therapeutic gene into cells, followed by expression and production of the ...Author: H. Eliyahu, Y. Barenholz, A. J. Domb
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