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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751499/
However, poor cellular uptake and rapid in vivo degradation of DNA-based therapeutics necessitate the use of delivery systems to facilitate cellular internalization and preserve their activity. This review discusses the basis of structural design, mode of action, and applications of DNA-based therapeutics.Author: Siddhesh D. Patil, David G. Rhodes, Diane J. Burgess
https://link.springer.com/article/10.1208%2Faapsj070109
Mar 01, 2005 · This review discusses the basis of structural design, mode of action, and applications of DNA-based therapeutics. The mechanisms of cellular uptake and intracellular trafficking of DNA-based therapeutics are examined, and the constraints these transport processes impose on the choice of delivery systems are summarized.Author: Siddhesh D. Patil, David G. Rhodes, Diane J. Burgess
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866338/
Liposomes can be used as DNA drug delivery systems either by entrapping the DNA-based therapeutics inside the aqueous core or complexing them to the phospholipids lamellae. Liposome can also be used for specialized gene delivery options that include long circulation half-life, sustained and targeted delivery.
https://www.researchgate.net/publication/7615814_DNA-based_therapeutics_and_DNA_delivery_systems_A_comprehensive_review
DNA-based therapeutics and DNA delivery systems: A comprehensive review ... therapeutics necessitate the use of delivery systems to facilitate cellular internalization and preserve their activity ...
https://pubs.acs.org/doi/10.1021/acsnano.8b07858
Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral gene delivery systems including lipid-based DNA therapeutics offer the opportunity to deliver an encoding gene sequence specifically to the target tissue and thus enable the expression of …Author: Jonas Buck, Philip Grossen, Pieter R. Cullis, Jörg Huwyler, Dominik Witzigmann, Dominik Witzigmann
http://dipbsf.uninsubria.it/monti/BFPN%202009/aapsj070109.pdf
in vivo degradation of DNA-based therapeutics necessitate the use of delivery systems to facilitate cellular internaliza-tion and preserve their activity. This review discusses the basis of structural design, mode of action, and applications of DNA-based therapeutics. The mechanisms of cellular uptake and intracellular trafficking of DNA-based ...
https://www.researchgate.net/publication/44630408_DNA_as_therapeutics_An_update
DNA as Therapeutics; an Update P. SARASWAT*, R. R. SONI 1 , A. BHANDARI 2 AND B. P. NAGORI 3 Mahatma Gandhi Medical College and Hospital, RIICO …
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
Outside of the classical drug delivery systems, there are also new strategies to develop siRNA therapeutics. For instance, DNA origami, RNA nanoparticles, SNA were utilized to deliver siRNA to tumor cells and other forms of RNA can activate RNAi.Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
http://www.biopharminternational.com/bioprocessing-technology-trends-rna-based-therapeutics-and-vaccines
Jul 01, 2016 · The dominant and most-studied strategy for the delivery of RNA-based therapeutics is lipid-based delivery systems. One successful platform is the use of stable nucleic acid lipid particles (SNALPs), which are lipid particles formed from a fusogenic lipid, cationic lipid, and PEG-lipid mixture.
https://www.ijpsonline.com/articles/dna-as-therapeutics-an-update.html
Liposomes can be used as DNA drug delivery systems either by entrapping the DNA-based therapeutics inside the aqueous core or complexing them to the phospholipids lamellae. Liposome can also be used for specialized gene delivery options that include long circulation half-life, sustained and targeted delivery .Author: P Saraswat, RR Soni, A Bhandari, BP Nagori
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