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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197064/
Anti-gp120 aptamer-siRNA chimera is designed and evaluated its efficacy as cell-type specific siRNA delivery system As shown in Figure 5A, the aptamer and sense strand segment of the siRNAs contained nuclease-resistant 2'-Fluoro UTP and 2'-Fluoro CTP and are synthesized from corresponding dsDNA templates by in vitro bacteriophage transcription.Author: Jiehua Zhou, Haitang Li, Jane Zhang, Swiderski Piotr, John Rossi
https://www.jove.com/video/2954/development-cell-type-specific-anti-hiv-gp120-aptamers-for-sirna
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery Jiehua Zhou 1 , Haitang Li 1 , Jane Zhang 2 , Swiderski Piotr 3 , John Rossi 1 1 Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope , 2 Graduate School of Biological Sciences, Beckman Research Institute of City of Hope , 3 Shared Resource-DNA/RNA Peptide, Beckman …Author: Jiehua Zhou, Haitang Li, Jane Zhang, Swiderski Piotr, John Rossi
https://www.researchgate.net/publication/51469006_Development_of_Cell-type_specific_anti-HIV_gp120_aptamers_for_siRNA_delivery
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery Jiehua Zhou 1 , Haitang Li 1 , Jane Zhang 2 , Swiderski Piotr 3 , John Rossi 1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · The Development of Cell-Specific Aptamers for Targeted Delivery. Cell-type-specific aptamers targeting cell surface biomarkers or receptors have been used for targeted delivery of various entities (Table 1 and Fig. 1). Decoration of DNA or RNA aptamers on delivery vehicles confers selectivity in cell type interactions and can result in cellular internalization in the target cells, thereby …Author: Jiehua Zhou, John J. Rossi
http://core.ac.uk/display/8631124
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery . By Jiehua Zhou, Haitang Li, ... it is highly desirable to develop a targeted intracellular siRNA delivery approach to specific cell populations or tissues. The HIV-1 gp120 protein, a glycoprotein envelope on the surface of HIV-1, plays an important role in viral ...
https://www.jove.com/video/2954/entwicklung-von-zell-spezifischen-anti-hiv-gp120-aptamere-fr-sirna?language=German
Entwicklung von Zell-spezifischen Anti-HIV-gp120-Aptamere für siRNA Jiehua Zhou 1 , Haitang Li 1 , Jane Zhang 2 , Swiderski Piotr 3 , John Rossi 1 1 Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope , 2 Graduate School of Biological Sciences, Beckman Research Institute of City of Hope , 3 Shared Resource ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)38782-2
In addition two types of dual inhibitory function anti-gp120-mediated delivery systems were constructed: 1) aptamer-siRNA chimeras and 2) aptamer-stick-siRNAs in which both the aptamer and siRNA portion are chemically synthesized, and the chimeras are created by complementary 16-nt ‘sticky’ bridge sequences to form enough stable base-paired chimeras.
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