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https://www.sciencedirect.com/science/article/pii/S0378517302006385
In case of buccal (poly)peptide drug delivery systems based on mucoadhesive polymers, for instance, a high stability of the carrier-matrix would reduce the disintegration and dissolution of the drug delivery system in the oral cavity (Rathbone et al., 1994). A rapid disintegration of the delivery system would lead to drug release to non-target sites.Author: Nina Langoth, Jochen Kalbe, Andreas Bernkop-Schnürch
https://pdfs.semanticscholar.org/8bfb/ff8b72dab18adca90cde77d6654fcfc082ec.pdf
DISADVANTAGES OF BUCCAL DRUG DELIVERY SYSTEM [2] 1) Low permeability of the buccal membrane: specifically when compared to the sublingual membrane. 2) Smaller surface area. The total surface area of the membranes of the oral cavity available for drug absorption is 170 cm 2 of which ~50 cm represents non-keratinized tissues, including the buccal membrane.
https://www.pharmatutor.org/articles/buccal-drug-delivery-system
Buccal delivery of drugs provides an attractive alternative to the oral route of drug administration, particularly in overcoming deficiencies associated with the latter mode of dosing. Buccal mucosa consist of stratified squamous epithelium supported by a connective tissue lamina propia (Squire and Wertz,...
https://ijpsr.com/bft-article/an-overview-on-buccal-drug-delivery-system/?view=fulltext
This review article is an overview of buccal drug delivery systems encompassing a review of oral mucosa, formulation considerations for buccal drug delivery system, theories and mechanism of mucoadhesion, different mucoadhesive formulations for buccal drug delivery and active ingredients delivered via the buccal route.
https://www.researchgate.net/publication/10931260_Development_of_buccal_drug_delivery_systems_based_on_a_thiolated_polymer
The review aims the development in the buccal adhesive drug delivery systems to provide basic principles to the young researchers which will be helpful in overcoming the difficulties associated ...
https://www.pharmaceutical-journal.com/news-and-analysis/research-and-developments-in-buccal-and-sublingual-drug-delivery-systems/11098641.fullarticle?firstPass=false
Research and developments in buccal and sublingual drug delivery systems. Oral administration of medicines still enjoys a hallowed place in drug delivery systems and, unsurprisingly, still takes the lion’s share of the pharmaceuticals marketplace.
https://www.imedpub.com/articles/a-comprehensive-review-on-buccal-drug-delivery-system.pdf
2. Reservoir type: The buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesive. An impermeable backing is applied to control the direction of drug delivery; to reduce patch deformation and disintegration while in the mouth; and to prevent drug loss.
https://drug-dev.com/buccal-delivery-dissolvable-film-format-evolves-to-buccal-drug-delivery-applications/
In the case of buccal applications, it is up to the product designer to determine at what point the thickness or overall size of the buccal drug delivery device becomes unacceptable to the patient. Because there is a limitation in the size of the final buccal product, typically 1 to 5 square centimeters, this limited surface area dictates that the APIs must be fairly potent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436075/
Investigations on the buccal drug delivery systems . Several buccal drug delivery devices have been developed at the laboratory scale by many researchers either for local or systemic actions. They are broadly classified into (i) Solid buccal adhesive dosage forms (ii) Semi-solid buccal adhesive dosage forms (iii) Liquid buccal adhesive dosage forms.Author: P Chinna Reddy, Chaitanya K.S.C., Y Madhusudan Rao
https://www.academia.edu/2325046/A_REVIEW_ON_BUCCAL_DRUG_DELIVERY_SYSTEM
Buccal drug delivery has gained significant attention and momentum since it offers remarkable advantages. The main objective of this review article is to describe the buccal drug delivery system of …
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