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https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
The major obstacle facing efficient gene therapy is the development of reliable delivery vehicles, which are both nontoxic and biocompatible and possess efficient cell-specific gene delivery. Previously, hybrid delivery vehicles comprising anionic liposomes and cationic polymers have been used successfully for gene therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079258/
Mar 01, 2011 · Various bioreducible polymers have been developed for gene delivery systems because the above unique features make bioreducible polymers as ideal gene delivery carriers. This review will focus the initiation and recent advances in the development and application of bioreducible polymers for gene delivery systems.Author: Tae Il Kim, Sung Wan Kim, Sung Wan Kim
https://www.sciencedirect.com/science/article/pii/S0079670007000718
Along with innovative approaches for integrating the diverse collection of polymer tools and technologies, the future of gene delivery research rests on the continual development of robust analytical methods that can (1) accurately characterize the physicochemical characteristics of multifaceted vectors; (2) elucidate the mechanisms by which certain physicochemical features facilitate gene transfer…Author: Sharon Y. Wong, Jeisa M. Pelet, David Putnam
https://www.mdpi.com/1420-3049/24/20/3744
This review summarizes mechanistic aspects of gene delivery and the development of biodegradable polymers for gene delivery. The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a variety of genetic diseases.Author: T. J. Thomas, Heidar-Ali Tajmir-Riahi, C. K. S. Pillai
https://link.springer.com/10.1007/s41061-017-0183-y
Jan 15, 2018 · In this review, we focus on the design and development of precisely defined polymers for efficient gene delivery, illustrated with examples including dendrimers, peptide-based polymers, and sequence-defined oligoaminoamide oligomers. This is …Author: Dongsheng He, Hao Lin, Yinglan Yu, Lei Shi, Jiasheng Tu
https://www.sciencedirect.com/science/article/pii/S016777991830060X
These technologies can help to extend the flexibility and versatility in design of polymers for gene delivery. Along with the increasing understanding of the mechanisms of cellular internalization and intracellular trafficking, the emergence of more effective polymeric carriers with promising application potential is anticipated.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · Gene therapy has derived to provide a patient’s somatic cells with genetic information for producing specific therapeutic proteins to modulate genetic diseases. In order to get a successful design of gene delivery system, it must be required the complete understanding of interaction between targeting cell and gene delivery system.Author: YK Sung, SW Kim
https://www.researchgate.net/publication/7694030_Pack_DW_Hoffman_AS_Pun_S_and_Stayton_PS_Design_and_development_of_polymers_for_gene_delivery_Nat_Rev_Drug_Discov_4_581-593
Request PDF Pack, DW, Hoffman, AS, Pun, S and Stayton, PS. Design and development of polymers for gene delivery. Nat Rev Drug Discov 4: 581-593 The lack of safe and efficient gene-delivery ...
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