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https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Based on the large number of studies of off-the-shelf and specifically designed gene delivery polymers, much has been learned about the structure-function relationships of polymer vectors. With growing understanding of polymer gene delivery mechanisms and continued efforts of creative and talented polymer chemists,...Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
http://www.nature.com/articles/doi:10.1038/nrd1775
Jul 01, 2005 · Gene therapy's potential is great, but the lack of safe and efficient gene delivery methods is a limiting obstacle to clinical implementation. Gene delivery methods include recombinant viruses and synthetic materials such as lipids, polypeptides and polymers. Safety concerns limit the use of viral vectors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · A new non-viral DNA delivery vectors of the terplex systems and polyethylene glycol-grafted poly(L-lysine) as polymeric gene carriers were also developed for gene delivery systems [102–105]. The clinical evaluations have currently made in the field of biomedical applications [ …Author: YK Sung, SW Kim
https://aran.library.nuigalway.ie/handle/10379/4569
The overall aim of this project was to develop a safe and efficient polymer based gene delivery method to encourage the production of functional C7 protein and restore the mechanical stability at the BMZ in RDEB mouse skin.
https://www.sciencedirect.com/science/article/pii/S016777991830060X
Current Development of Polymeric Carriers. Gene delivery technologies may bring hope of combating diseases that have been pharmaceutically intractable. Viral vectors entered clinical trials as early as the 1990s ; however, the safety concerns involved have limited their broad use.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.201900213
With the rapid growth of immunotherapy in cancer treatment and knowledge accumulation in vector structure design, polymeric nonviral gene delivery systems may provide new hope for tumor therapy.Author: Lingjie Ke, Pingqiang Cai, Yun‐Long Wu, Xiaodong Chen
https://www.sciencedirect.com/science/article/pii/S007967001100030X
The design of efficient gene delivery vectors is a challenging task in gene therapy. Recent progress in living/controlled radical polymerizations (LRPs), in particular atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization providing a means for the design and synthesis of new polymeric gene vectors with well-defined compositions ...Author: F.J. Xu, W.T. Yang
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
The major obstacle facing efficient gene therapy is the development of reliable delivery vehicles, which are both nontoxic and biocompatible and possess efficient cell-specific gene delivery. Previously, hybrid delivery vehicles comprising anionic liposomes and cationic polymers have been used successfully for gene therapy.
https://pubs.acs.org/doi/pdf/10.1021/mp500656v
can be satisfied through the development of new drug delivery systems. With advances in molecular biology and biotechnology ... Ideally, the vectors appropriate for gene delivery should possess the following merits. First, the vectors have to compact ... The Design of Supporting Polymeric Nanocores. To date, polyethylenimine (PEI),20,21 poly L ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079258/
Mar 01, 2011 · Bioreducible polyethylenemines (PEIs) PEI is one of most efficient polymeric gene delivery carriers which can condense pDNA at low weight ratios (polymer/pDNA) due to its high charge density and induce high transgene expression by efficient endosomal escape of polyplexes through “proton sponge effect” hypothesis,...Author: Tae Il Kim, Sung Wan Kim, Sung Wan Kim
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