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https://www.ncbi.nlm.nih.gov/pubmed/29958437
Jun 28, 2018 · This review highlights the utilization of dendron-polymer conjugates as building blocks for the fabrication of nanosized drug delivery vehicles. The examples given provide an overview of the evolution of these delivery platforms, from simple micellar containers to smart stimuli- responsive drug delivery systems through their design at the ...Author: Burcu Sumer Bolu, Rana Sanyal, Amitav Sanyal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/
The exclusive properties viz. well-defined structure, polyvalent character and monodispersity make them effective nanosystems for drug delivery applications. The current review has emphasized on the considerable opportunities that dendrimers offer in resolving fundamental issues of solubility, drug delivery and targeting of drug molecules.
https://en.wikipedia.org/wiki/Dendrimer
There are three methods for using dendrimers in drug delivery: first, the drug is covalently attached to the periphery of the dendrimer to form dendrimer prodrugs, second the drug is coordinated to the outer functional groups via ionic interactions, or third the dendrimer acts as a unimolecular micelle by encapsulating a pharmaceutical through ...
https://www.mdpi.com/1420-3049/23/7/1570/htm
This review highlights the utilization of dendron-polymer conjugates as building blocks for the fabrication of nanosized drug delivery vehicles. The examples given provide an overview of the evolution of these delivery platforms, from simple micellar containers to smart stimuli- responsive drug delivery systems through their design at the macromolecular level. Variations in chemical ...Author: Burcu Sumer Bolu, Rana Sanyal, Amitav Sanyal
https://pubs.rsc.org/en/content/articlelanding/2016/tb/c6tb00688d#!
Smart nanoscale drug delivery systems have been investigated as potential candidates for drug delivery vehicles. Here, we used a breast cancer model to determine if the enzyme-responsive Janus dendron (mPEGylated dendron–PVGLIG–DOX) conjugate-based nanoscale system would be an effective and safe drug delivery vehicle for chemotherapy.
https://www.pharmatutor.org/articles/dendrimers-carrier-for-oral-drug-delivery-system
Dendrimers are normally used as carriers for drug delivery especially for oral, ocular and transdermal delivery. Oral drug delivery system are very important to the field of medicine, since most of the common illness are treated via oral route. Encapsulation and conjugation of drug with dendrimers have shown immerse employment for delivery of ...
https://www.pharmatutor.org/articles/dendrimers-novel-drug-delivery-overview
Figure 2: Dendrimer and Dendron. ADVANTAGES OF DENDRIMERS 1. In target drug delivery: Dendrimers are suitable for targeting solid tumours due to increased permeability, limited drainage in tumour vasculature which will lead to accumulation of macromolecules in …
https://www.sciencedirect.com/science/article/pii/S0021979717301996
Jun 15, 2017 · The nanocomposite is proposed as model for the development of surface mediated drug delivery systems. We were successful in the formation and characterization of pure (dendrons) and composite (drug-dendron) stable and reproducible monolayers, and their transfer to solid substrates.Author: Nahir Dib, Ana Lucía Reviglio, Luciana Fernández, Gustavo Morales, Marisa Rosana Santo, Luis Alberto...
https://www.sigmaaldrich.com/technical-documents/articles/materials-science/nanomaterials/dendrimers-dendrons.html
We offer a wide range of monodisperse dendrimer molecules with four different chemical structures (PAMAM, phosphorous, polypropylenimine, polylysine) and numerous distinct terminal surface groups.To expand the range of dendritic tools for your materials chemistry research, we are pleased to offer two types of dendritic macromolecules: polyester dendrons and hyperbranched polymers based on 2,2 ...
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00931
Mar 28, 2016 · In this study, drug conjugated micellar constructs are fabricated using triblock dendron–linear polymer conjugates where a hydrophilic linear polyethylene glycol (PEG) chain is flanked by well-defined hydrophobic biodegradable polyester dendrons bearing an antiangiogenic drug, combretastatin-A4 (CA4).Author: Burcu Sumer Bolu, Ece Manavoglu Gecici, Rana Sanyal
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