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https://pubs.rsc.org/en/content/articlelanding/2012/nj/c1nj20408d#!
Dendrimers as non-viral vectors for siRNA delivery ... The present review offers a brief overview of the current status of dendrimers as siRNA delivery vectors, focusing on the different dendrimers investigated for their siRNA delivery ability and the related structural alterations employed to improve their safety and efficiency for this purpose.
https://www.researchgate.net/publication/255755059_Dendrimers_as_Non-Viral_Vectors_for_siRNA_Delivery
Dendrimers as Non-Viral Vectors for siRNA Delivery. ... overview of the current status of dendrimers as siRNA delivery vectors, focusing on the different dendrimers investigated for their siRNA ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816686/
Since their discovery, PAMAM dendrimers have gained interest as non-viral nucleic acid delivery vectors due to their high aqueous solubility, high transfection efficiency and minimal cytotoxicity. The positively charged primary amine groups on the surface of these dendrimers allows electrostatic interaction with negatively charged DNA molecules.Author: Swati Biswas, Vladimir P. Torchilin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130907/
Jan 12, 2011 · The use of non-viral vectors has been proposed to overcome the aforementioned drawbacks of their viral counterparts. However, one of the main problems of such non-viral gene vectors is their low transfection efficiency compared with viral vectors (2, 3). Transgene expression, or siRNA delivery mediated by non-viral vectors, is the result of ...Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://www.academia.edu/13276112/Dendrimers_as_non-viral_vectors_for_siRNA_delivery
Dendrimers as non-viral vectors for siRNA delivery
https://www.hindawi.com/journals/tswj/2013/630654/
Considering the safety issues and other drawbacks of viral approach, the nonviral vectors for siRNA delivery are increasingly concerned as the alternatives of viral ones. Among versatile non-viral vectors, dendrimer-based siRNA carriers have been gradually explored …Author: Jiangyu Wu, Weizhe Huang, Ziying He
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of low cost, more reproducible and do not present DNA size limit.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.sciencedirect.com/science/article/pii/S0378517319301966
May 01, 2019 · Non-viral gene delivery vectors studied in the gene therapy applications are often designed with the cationic nitrogen containing groups necessary for binding and cell release of nucleic acids. Disadvantage is a relatively high toxicity which restricts the in vivo use of such nanoparticles.Author: Regina Herma, Dominika Wrobel, Michaela Liegertová, Monika Müllerová, Tomáš Strašák, Marek Maly, Ale...
https://onlinelibrary.wiley.com/doi/full/10.1111/jphp.12104
Jul 19, 2013 · Dendrimers for non‐viral gene delivery. Various viral and non‐viral gene delivery systems have been developed for the delivery of genetic materials to different organs, tissues and cells. While viral vectors are the most capable vehicles, their limitations include their high carcinogenicity and immunogenicity in vivo.Author: Sahil P. Chaplot, Ilva D. Rupenthal
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/non-viral-vector
Non-viral vectors. Gene delivery based on non-viral vectors has attracted much attention due to their universal application range and high safety level of delivery. 5 A number of nanoparticle delivery systems based on polymers and liposomes have been developed. Furthermore, physical approaches including, for example, electroporation and gene ...
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